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Understanding Motivation for IV Alcohol Use in People with Alcohol Use Disorder

This study aims to understand why people with alcohol use disorder (AUD) are motivated to drink alcohol. Researchers will investigate how a person's desire for rewards, emotions, and thinking abilities affect their motivation to self-administer (give themselves) intravenous alcohol (alcohol given through a vein). Participants will receive intravenous alcohol (6% ethanol v/v in saline) and complete questionnaires. The study will measure changes in craving, mood, and how much alcohol participants choose to self-administer. This study is looking for 210 participants between 21 and 65 years old who have reported alcohol use in the past 30 days and meet criteria for mild-to-severe AUD. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 210 participants. It combines an alcohol challenge with a progressive ratio self-administration method.
What's involved
You would complete questionnaires, undergo an intravenous alcohol administration, and press a button to receive additional doses of intravenous alcohol.
Compensation
Not stated in the trial record.
Follow-up
Primary outcomes, such as incentive salience, craving, and self-administration, will be measured at 10 hours.

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NCT06494891

Motivation for IV Alcohol Self-Administration in Humans

Recruiting
PHASE2Ages 21–65Interventional
University of California, Los Angeles
~210 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Intravenous Alcohol

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incentive Salience, Craving, and Self-Administration
Measured over 10 hours
+2 more outcomes measured

Conditions

Alcohol Use Disorder

Explore related trials

Alcohol use disorder

Where it's being run

1 sites across 1 states
California1

Who to contact

Jessica Jenkins, MS
[email protected]
310-206-6756
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Oral contraceptives
Contraceptive sponge
Patch
Double barrier
Intrauterine contraceptive device
Etonogestrel implant
Medroxyprogesterone acetate contraceptive injection
Hormonal vaginal contraceptive ring
Complete abstinence from sexual intercourse 7. Have clinically significant abnormalities identified in the physical exam that may interfere with safe study participation (e.g. unstable cardiac, renal, or liver disease; diabetes; uncontrolled hypertension; or HIV) 8. Exceed Grade 2 laboratory abnormalities, based on FDA Guidance Document "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials" 9. Currently use any medications known to interact with alcohol, including: antidepressants, anticonvulsants, opioids, benzodiazepines, medications for diabetes, and medications that affect alcohol metabolism 10. Have an intense fear of needles or have had adverse reactions to needle puncture 11. Have any other circumstances that, in the opinion of the investigators, would not be a good fit for study participation

What this trial measures

  • Incentive Salience, Craving, and Self-Administration10 hours

    Scores on the incentive salience factor of the ANA will correlate with craving during the challenge and self-administration during the progressive ratio.

  • Negative Emotionality, Negative Mood, and Self-Administration10 hours

    Scores on the negative emotionality factor of the ANA will correlate with relief from negative mood during the challenge and self-administration during the progressive ratio.

  • Executive Dysfunction, Loss of Control, and Self-Administration10 hours

    Scores on the executive dysfunction factor of the ANA will correlate with loss of control during the challenge and self-administration during the progressive ratio.