Cognition, Flavonoids, Exercise, Gut Microbiome

{ "Blueberry and Exercise for Mild Cognitive Decline", "This study is looking at how a daily blueberry powder supplement and/or regular walking might affect thinking and memory in older adults with mild cognitive decline. You could be eligible if you are between 65 and 85 years old, a non-smoker, and have a specific score on a memory test (MoCA test score of 24.1-25.2). The study aims to see if combining blueberries and exercise can improve cognitive function, possibly by changing your gut microbiome. Participants will receive either blueberry powder or a placebo powder, and will either walk or do stretching exercises. The main goal is to see changes in your thinking abilities after 6 and 12 weeks. The current status of the study is unclear, but it plans to enroll 240 participants.", "design": "This is a randomized clinical trial, meaning participants are assigned by chance to one of four groups. It involves 240 participants, with 200 expected to complete the study.", "commitments": "You would take a daily powder supplement and participate in five 45-minute exercise sessions per week for 12 weeks. Blood, urine, and stool samples will be collected, and cognitive function and cardiorespiratory fitness will be measured at the start, 6 weeks, and 12 weeks.", "compensation": "Not stated in the trial record.", "follow_up": "Cognitive function will be measured at 6 and 12 weeks after starting the study interventions.", }

Study design: Not specified.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Cognition, Flavonoids, Exercise, Gut Microbiome

Recruiting

NAAges 65–85InterventionalBasic science

Appalachian State University

~240 participants

Updated 2025-03-12 on ClinicalTrials.gov

What's tested:BlueberryWalkingPlaceboStretching

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Cognition

Measured over Change from pre-study to 6-weeks and 12-weeks

Conditions

Cognitive Decline, Mild

NCT06495190

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

Appalachian State University Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolinastudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

David C Nieman, DrPH · PRINCIPAL_INVESTIGATOR · Appalachian State Univ

Who to contact

David C Nieman, DrPH

[email protected]

8287730056

Email the study team

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Eligibility criteria

Inclusion

Score on the Montreal Cognitive Assessment (MoCA test) of 24.1-25.2 that indicates mild cognitive decline. The MoCA test score ranges from 0 to 30, with higher scores from 26 to 30 considered normal.

Healthy, non-smoking male or female participants 65 to 85 years of age.

Capable of engaging in a supervised 12-week exercise training program (brisk walking or stretching).

Physically inactive (defined as less than 150 min/week moderate or less than 75 minutes vigorous aerobic and/or resistance exercise during the past 4 weeks).

Willingness to be randomized to one of four groups.

Willingness to provide blood, urine, and fecal samples (3 each),

Willingness to avoid blueberry intake during the 12-weeks study (other than what is provided through the study).

Willingness to maintain current diet and physical activity patterns during the study (other than what is prescribed as a part of the study), and make no formal attempts to lose or gain body weight.

Willingness to be a participant in this study only and not enter any other studies.

Exclusion

Allergy to blueberries.

Diagnosis of Type I or Type 2 diabetes.

Chronic cardiovascular, metabolic, or renal condition that is uncontrolled (controlled defined as stable for 6 months or more).

History of signs or symptoms during rest or physical activity such as chest discomfort, unreasonable breathlessness, dizziness, fainting, or blackouts.

Use of any prescription or over-the-counter drug intended to support cognition or with known cognitive side effects.

Any other concurrent condition or use of medications or supplements which, in the opinion of the study clinician would preclude participation in this study.

Diagnosis of dementia.

What this trial measures

CognitionChange from pre-study to 6-weeks and 12-weeks
Cognitive function using the Cambridge Neuropsychological Test Assessment Battery (CANTAB, Cambridge Cognition, Ltd).

Trialytics