Prebiotics for Ulcerative Colitis

This study is looking at how prebiotics, a type of dietary supplement, might affect the gut health and microbiome (the community of tiny organisms in your gut) in people with ulcerative colitis (UC) or Crohn's disease. Researchers believe that diet, especially plant-based foods, can improve the gut microbiome, which may impact inflammatory bowel disease (IBD) outcomes. You might be able to join if you are 18 to 85 years old, have biopsy-proven UC, and are experiencing active symptoms. The study will measure if taking a daily prebiotic supplement for 8 weeks can lead to clinical remission (a period where symptoms are reduced or absent), changes in a marker of inflammation called fecal calprotectin, and changes in your gut's microbial composition. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 70 participants. You will be randomly assigned to take a prebiotic supplement for 8 weeks, either starting at week 0 or week 8.
What's involved
You will take a daily prebiotic supplement for 8 weeks. Stool samples will be collected at weeks 0 and 8, and your dietary composition will be assessed at baseline and over 16 weeks.
Compensation
Not stated in the trial record.
Follow-up
Clinical remission, fecal calprotectin, and microbial composition will be measured at Week 8.

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NCT06495658

Impact of Prebiotics in Ulcerative Colitis

Recruiting
NAAges 18–85Interventional
University of California, Los Angeles
~70 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:Prebiotic

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical remission
Measured over Week 8
+2 more outcomes measured
Crohn Disease
Ulcerative Colitis
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Ages 18 to 85 years old
History of biopsy-proven ulcerative colitis (UC)
Active symptoms (SCCAI \>2)
Concomitant use of 5-aminosalicylates, immunomodulators, and corticosteroids will be permitted, although initiation or dose adjustment must not have occurred within 30 days prior to enrollment.
Concomitant use of biologic therapy will be permitted, although initiation or dose adjustment must not have occurred within 60 days prior to enrollment.
Prior probiotics or other dietary supplements use is permitted but will be asked to be discontinued during the course of the trial

Exclusion

Prior colectomy
Hospitalization
Urgent need for abdominal surgery
Unstable major medical condition
Active malignancy under treatment
Active alcohol or non-cannabinoid substance abuse
Pregnancy or lactation
Concerns for non-compliance
  • Clinical remissionWeek 8

    Clinical remission will be defined as a Simple Colitis Clinical Activity Index (SCCAI) \< 4. Range of SCCAI is 0-20 (higher is more severe).

  • Change in fecal calprotectinWeek 8

    Fecal calprotectin is a stool test that measures intestinal inflammation

  • Microbial compositionWeek 8

    Microbial composition includes a measurement and characterization of the relative quantity of genera and species.