Impact of Obicetrapib and Obicetrapib Plus Repatha on Lp(a) Levels

{ "Study of Obicetrapib and Repatha for High Lp(a)", "This study is looking at how two medications, obicetrapib and evolocumab (also known as Repatha), affect levels of lipoprotein(a) or Lp(a). Lp(a) is a type of cholesterol that can increase your risk of heart disease. You may be able to join if you are between 18 and 75 years old and have high Lp(a) levels (at least 20 mg/dL or 50 nmol/L) and certain other cholesterol levels. The main goal is to see how much Lp(a) levels change after 8 weeks of taking obicetrapib daily along with evolocumab every two weeks. The study is currently unclear about its recruitment status and plans to enroll 69 participants.", "design": "This is an open-label study, meaning you and your doctors will know which medications you are receiving. It plans to enroll 69 participants to evaluate the effects of the medications.", "commitments": "You would have your Lp(a) tested at the start, take obicetrapib daily for 8 weeks, have Lp(a) retested, then take obicetrapib daily and evolocumab every two weeks for another 8 weeks, and have Lp(a) retested again.", "compensation": "Not stated in the trial record.", "follow_up": "Your Lp(a) levels will be measured at 16 weeks from the start of the study, after 8 weeks on the combination therapy.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06496243

Impact of Obicetrapib and Obicetrapib Plus Repatha on Lp(a) Levels

Recruiting
PHASE2Ages 18–75InterventionalTreatment
NewAmsterdam Pharma
~69 participants
Updated 2026-04-09 on ClinicalTrials.gov
What's tested:obicetrapib 10 mg + obicetrapib/evolocumab 140 mg Q 2 weeks

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To evaluate the effect of evolocumab in combination with obicetrapib on lipoprotein (a) (Lp[a]).
Measured over 16 weeks from baseline; 8 weeks on combination therapy
Dyslipidemias
1 sites across 1 states
Pennsylvania1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Lp(a): \>=50 mg/dL (\>=125 nmol/L) for cohort 1 (FILLED) and Lp(a) \>= 20 mg/dL (\>= 50 nmol/L) to \<50 mg/dL (\< 125 nmol/L) for cohort 2
LDL-C \>70 mg/dL
TG \< 400mg/dL (\<4.52 mmol/L)

Exclusion

HbA1c\>=10 or FPG \>=270 mg/dL
CV events within 3 months of screen
  • To evaluate the effect of evolocumab in combination with obicetrapib on lipoprotein (a) (Lp[a]).16 weeks from baseline; 8 weeks on combination therapy

    Lp(a) change on combination therapy