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Patient-Controlled Liquid Acetaminophen for Postoperative Pain

This study is testing a new way to give pain medication after shoulder surgery. It's looking at whether patients can safely and effectively control their own doses of liquid acetaminophen (Tylenol) using a special pump, compared to getting acetaminophen pills from a nurse. We want to see if patients like this method and if it's practical for hospitals. You might be able to join if you are an adult having total shoulder or reverse total shoulder arthroplasty (shoulder replacement surgery). The study aims to enroll 24 participants and is currently unclear on its recruitment status. Success for this study means many patients choose to participate and stick with the new method.

Study design
This is an interventional pilot study with a planned enrollment of 24 adult participants. It compares patient-controlled liquid acetaminophen to nurse-administered acetaminophen pills.
What's involved
You would fill out a paper questionnaire and keep a pain diary. Nurses involved would also fill out a questionnaire.
Compensation
Not stated in the trial record.
Follow-up
Participant adherence to the study protocol and nurse questionnaires are measured for up to 12 months, and on study days 0, 1, 2, and 3.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06498713

Patient Controlled Administration of Liquid Acetaminophen

Completed
PHASE1Ages 18+InterventionalTreatment
Yale University
~24 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:Acetaminophen 650 mg Oral TabletAcetaminophen 650mg LiquidCADD pump

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Participant enrollment rate
Measured over up to 12 months
+2 more outcomes measured

Conditions

Pain
Pain, Postoperative

Explore related trials

Pain

Where it's being run

1 sites across 1 states
Connecticut1

Study leadership

  • Jinlei Li, MD, PhD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult patients older than 18 years old admitted to SRC for total shoulder and reverse total shoulder arthroplasty
The nurse who will administer acetaminophen to a study patient.

Exclusion

Pregnant patient
Patients that cannot swallow pills or cannot take liquid (for example due to risk of aspiration)
Emergency surgery
Chronic pain
On home opioids, any other pain modulating medications including benzodiazepine, Neurontin, ketamine.
Past medical or social history of substance abuse disorder, including ethanol misuse disorder, marijuana misuse disorder
History of any psychiatric disorders including anxiety, depression, any cognitive dysfunction
Any patients who cannot provide informed consents on their own (those who would need Legally Authorized Representatives (LARs) or surrogates)
Liver dysfunction limiting amount of safe oral acetaminophen
baseline hyperbilirubinemia (ex: chronic liver disease, Gilbert's)
patients unable to take PO
Patients with neurologic, neuromuscular, or movement disorders unable to drink from a cup.
any nurse who is not involved in the direct care of a study patient, or who is not comfortable with setting up the PCA pump.

What this trial measures

  • Participant enrollment rateup to 12 months

    The percentage of participants that enroll

  • Participant adherence to the study protocolup to 12 months

    Percentage of participants that withdraw from treatment group, i.e. switch from patient controlled liquid group to the nurse-administered pill control group

  • Nurse QuestionnaireStudy day 0, 1, 2 and 3

    Nurse ranking of patient controlled liquid oral acetaminophen vs. nurse-administered pill acetaminophen. (Mean score, Total Scale of 0-10: 0: much worse; 5:same; 10: much better)