Optimizing Oxygen Care in Critically Ill Patients

This study, called "Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients," is testing a new way to manage oxygen levels for critically ill patients on a breathing machine (mechanical ventilation). It involves providing education and real-time alerts through Epic (an electronic health record system) to help medical teams keep patients' oxygen saturation (SpO2) between 90-96%. The goal is to reduce how long patients need the breathing machine and prevent "occult hypoxemia" (hidden low oxygen levels). You might be able to join if you are 18 or older, in the ICU, and need a breathing machine. The study is looking to see if this approach increases the number of "ventilator-free days" (days you are off the breathing machine) within 30 days. The current status of the study is unclear.

Study design
This interventional study plans to enroll 3600 participants. It uses a cluster randomized design, meaning groups of hospitals will be randomly assigned to receive the intervention at different times.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, ventilator-free days, is measured at 30 days.

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NCT06501118

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Recruiting
NAAges 18+Interventional
University of Colorado, Denver
~3,600 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:EducationEpic notification alert

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ventilator Free Days (Phase I,II)
Measured over 30 Days
Respiratory Failure
Acute Hypoxemic Respiratory Failure
Acute Hypoxic Respiratory Failure
Hypoxemia
Hypoxia
Hypoxic Respiratory Failure
1 sites across 1 states
Colorado1
  • Neil Aggarwal, MD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

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Eligibility criteria

Inclusion

Admission to ICU and requiring invasive mechanical ventilation

Exclusion

Transferred patients from outside the UCHealth system\*:
Patients with pre-existing disease that requires chronic use of positive pressure ventilation delivered through a tracheostomy\*:
Pregnant women:
Prisoners
Patients receiving mechanical ventilation for less than twelve hours
  • Ventilator Free Days (Phase I,II)30 Days

    The number of days the patient will be free of mechanical ventilation