Mifepristone vs Misoprostol for Cervical Preparation

This study is comparing two medications, mifepristone and misoprostol, for cervical preparation (softening and opening the cervix) before a procedural abortion. Researchers want to see if one medication is better at achieving the intended dilation (how much the cervix opens) at the time of surgery. You may be able to join if you are a woman between 18 and 45 years old, speak English or Spanish, and are seeking an abortion for a single pregnancy between 12 and 16 weeks. The study is currently unclear on its recruitment status and plans to enroll 94 participants.

Study design
This is an interventional study comparing mifepristone and misoprostol, with a planned enrollment of 94 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at the time of surgery.

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NCT06502158

Mifepristone vs Misoprostol

Recruiting
PHASE1Ages 18–45InterventionalTreatment
Montefiore Medical Center
~94 participants
Updated 2026-07-24 on ClinicalTrials.gov
What's tested:MifepristoneMisoprostol

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants achieving Intended dilation
Measured over At time of surgery
Cervical Preparation
1 sites across 1 states
New York1
  • Antoinette Danvers, MD, MSCR, MBA · PRINCIPAL_INVESTIGATOR · Montefiore Medical Center

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Eligibility criteria

Inclusion

English or Spanish-speaking
Capacity to consent
Seeking induced abortion of a singleton pregnancy between 12 weeks, 0 days and 16 weeks, 6 days (based on age at day of surgery)

Exclusion

History of more than two prior Cesarean deliveries
Sonographic evidence of placenta previa
Sonographic concern for morbidly adherent placenta
Prior obstetric hemorrhage requiring transfusion
Obstructive cervical or lower uterine segment fibroid
Current therapeutic anticoagulation use
Cerclage in situ
History of more than one prior cervical excisional procedure
BMI greater than 50 kg/m\^2
  • Percentage of participants achieving Intended dilationAt time of surgery

    The proportion of participants achieving intended dilation at the start of the procedure will be summarized by treatment group and reported in percentages. Achievement of intended dilation will be determined by the attending surgeon. Overdilation resulting in passage of products of conception prior to time of surgery will be characterized as a treatment failure.