Understanding Exercise Response in Older Adults (M3AX)
This study, called M3AX, is looking at how older adults respond to a combination of endurance and resistance training. Researchers want to understand why some people benefit more from exercise than others. You might be able to join if you are 60 or older, don't have chronic diseases, haven't been in a structured exercise program recently, and can give informed consent. The study will measure your heart and lung fitness (cardiorespiratory fitness) and how well your muscles work (functional muscle quality) after 23 weeks of training. The goal is to help more older adults get the full health benefits of exercise. This study is currently unclear on its recruitment status and plans to enroll 250 participants.
- Study design
- This interventional study plans to enroll 250 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would participate in combined endurance and resistance training three times a week for 23 weeks. This includes cycling, treadmill, or elliptical workouts, and high-intensity interval training.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your cardiorespiratory fitness and functional muscle quality will be measured at 23 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
At a glance
Conditions
NCT06507189
Where you'd take part
This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Florida Institute for Human and Machine Cognition
Pensacola, Floridastudy coordinator listed
Recruiting
Oklahoma Medical Research Foundation
Oklahoma City, Oklahomastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Marcas Bamman · PRINCIPAL_INVESTIGATOR · Florida Institute for Human and Machine Cognition
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Cardiorespiratory fitness (CRF)23 weeks
A primary outcome of this investigation is cardiorespiratory fitness (CRF). The CRF is the amount of oxygen (ml/kg) that is used during exercise and how efficient you are using that oxygen. The exercise used to measure oxygen uptake is a stationary bicycle with increasing intensity until you are able to maintain pace. Your expired air is collected with a mask or mouthpiece and analyzed with an oxygen and carbon dioxide sensor.
- Functional muscle quality (fMQ)23 weeks
A primary outcome of this investigation is functional muscle quality (fMQ). This is a ratio of knee extension strength to thigh leanness. Knee extension strength is the maximum amount of weight you can successfully lift one time. Thigh lean mass is measured with the dual energy x-ray absorptiometry (DEXA). This is a common tool used to measure bone density, but it is very efficient at determining fat and lean masses partitioned in the body.