Intraosseous Morphine for ACL Reconstruction Pain
This study is looking at whether injecting morphine directly into the bone (intraosseous morphine) can help reduce pain and the need for opioid pain medication after surgery for an anterior cruciate ligament (ACL) tear. You might be able to join if you are between 18 and 40 years old and are having ACL reconstruction surgery using a specific type of graft (bone-to-bone autograft). The researchers will measure your pain levels and how much opioid medication you use after surgery to see if the intraosseous morphine is effective. This study plans to enroll 84 participants, but its current recruitment status is unclear.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 84 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your pain levels will be measured at 2, 6, and 12 weeks after surgery, and opioid use will be measured at 2 weeks post-surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction
At a glance
Conditions
NCT06511232
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Houston Methodist Research Institute
Houston, Texasno site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Robert Jack, MD · PRINCIPAL_INVESTIGATOR · The Methodist Hospital Research Institute
Who to contact
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Inclusion
Exclusion
What this trial measures
- Patient Pain Levels in the Post-Operative Period as assessed by a patient-reported post operative symptom journal.2 weeks postop, 6 weeks postop, 12 weeks postop
The study will measure patient-reported levels of pain on a daily basis (for a total of two weeks) with a symptom journal, which will ask patients to report on a variety of pain-related outcomes including levels of pain throughout different times of day, levels of nausea throughout different times of the day, and what pain medication(s) they are taking and at what time.
- Changes in Post-Operative Opioid Use2 weeks postop
To examine if the use of IO morphine will result in different levels of post-operative opioid use compared to SOC administration of morphine. This outcome will be assessed utilizing the daily symptom journal which will ask patients to complete daily logs of the pain medication that they take (what kind, what dose, when they took it, etc.) for two weeks following their operation.
- Patient Pain Levels in the Post-Operative Period as assessed by the Lysholm Knee Survey2 weeks postop, 6 weeks postop, 12 weeks postop
Participants will be asked to complete the Lysholm Knee survey at 2, 6, and 12 weeks postop which will assess patient progress following surgery such as pain, swelling, climbing stairs, using a crutch, etc. The Lysholm scale consists of eight items with each question response being assigned an arbitrary score on an increasing scale. The total score is the sum of each response to the eight questions and may range from 0-100 where higher scores indicate a better outcome with fewer symptoms or disability.