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Ketorolac for Pain After Lumbar Spinal Fusion

This study is looking at whether Ketorolac Tromethamine (an IV medication) can help reduce the amount of pain medication (opioids) needed after lumbar spinal fusion surgery. You may be able to join if you are between 18 and 85 years old, are having elective posterior lumbar instrumented fusion surgery (a type of back surgery), and can speak English. You cannot join if you have kidney problems. Half of the participants will receive Ketorolac Tromethamine and the other half will receive a placebo (an inactive substance like saline). The main goal is to see if Ketorolac Tromethamine leads to less opioid use in the first 48 hours after surgery. The study is currently unclear on its recruitment status.

Study design
This is a double-blind, randomized study, meaning neither you nor your doctors will know if you are receiving Ketorolac Tromethamine or a placebo. It plans to include 140 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will measure opioid use during your hospital stay and compare groups at 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06513208

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

Recruiting
PHASE4Ages 18–85InterventionalTreatment
University of Maryland St. Joseph Medical Center
~140 participants
Updated 2025-12-22 on ClinicalTrials.gov
What's tested:Ketorolac TromethaminePlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ketorolac results in decreased post-op opioid use when administered in the first 48 hours (measured by calculating the total amount of MME utilized during the patient's inpatient stay and comparing the control and experimental groups).
Measured over 12 months

Conditions

Lumbar Spinal Fusion

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Lumbar spinal fusion

NCT06513208

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Maryland St. Joseph Medical Center

    Towson, Marylandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Aja Janyavula
[email protected]
410-427-5459
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

18-85 years old (inclusive)
Elective posterior lumbar instrumented fusion
One or two level fusion
Consent to participate in study and willing to adhere to study follow up
English proficiency

Exclusion

\< 18 or \> 85 years old
History of renal failure, dialysis, or creatinine over 1.50 mg/dl
Active or recent smoker (active within past 6 months)
Revision surgery
Auto/worker compensation
Active cancer or history of chemotherapy in past 6 months
Active narcotic use within 3 months of surgery date
Infection at operative levels
Any allergies to NSAIDs or Opioids

What this trial measures

  • Ketorolac results in decreased post-op opioid use when administered in the first 48 hours (measured by calculating the total amount of MME utilized during the patient's inpatient stay and comparing the control and experimental groups).12 months