Fiber and Calcium Absorption in Older Men

This study is looking at how a dietary supplement called soluble corn fiber affects how older men absorb calcium. Researchers want to see if this fiber can help improve bone health, especially since bone fractures are a big problem for older men. They will study 30 older male Veterans to understand if soluble corn fiber increases calcium absorption and how the gut microbiome (the community of tiny organisms in your intestines) might play a role. The main goal is to measure how much calcium is absorbed after 4 and 12 weeks of taking the fiber. You might be able to join if you are a male Veteran aged 60 or older, and do not have certain health conditions like severe kidney disease or very low vitamin D levels.

Study design
This is an interventional crossover study, meaning participants will likely receive both the soluble corn fiber and a comparison treatment at different times. The study plans to enroll 30 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Calcium absorption will be measured at week 4 and week 12 of study participation, at the end of each treatment phase.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06519877

Fiber and Calcium Absorption in Older Men

Recruiting
PHASE2Ages 60+Interventional
VA Office of Research and Development
~30 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Soluble corn fiber

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Intestinal fractional calcium absorption
Measured over At week 4 and week 12 of study participation (at the end of each treatment phase x2)
Aging

NCT06519877

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • San Francisco VA Medical Center, San Francisco, CA

    San Francisco, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Karin C Wu, MD · PRINCIPAL_INVESTIGATOR · San Francisco VA Medical Center, San Francisco, CA

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Eligibility criteria

Inclusion

Male Veterans 60 years of age

Exclusion

History of malabsorption
Hypercalcemia (corrected Ca \> 10.2 mg/dL)
Vitamin D insufficiency (25OHD \< 30 ng/mL)
Chronic kidney disease stage 3B or worse (CrCl \< 45 mL/min)
Severe hypogonadism (AM fasting serum total testosterone \< 150 ng/dL)
Daily use of proton pump inhibitor
Use of medication(s) known to affect calcium metabolism
Use of medications or supplements that could impact gut microbiota in the previous 3 months (antibiotics or commercially available probiotics or prebiotics.
Presence of a condition or abnormality that in the opinion of the Investigator that would compromise the safety of the patient or the quality of the data.
  • Intestinal fractional calcium absorptionAt week 4 and week 12 of study participation (at the end of each treatment phase x2)

    Dual stable calcium isotopic tracer method