Understanding Blood Flow in Aging Women

This study aims to understand how blood vessels adapt in aging women, focusing on the sympathetic nervous system (which controls many body functions, including blood pressure). Researchers will infuse different medications directly into an artery in your arm, including Norepinephrine, Isoproterenol, Acetylcholine, Nitroprusside, and Estrogen, to see how your blood flow changes. The main goal is to measure how much your forearm blood flow changes during these infusions. You may be able to join if you are a woman between 18 and 70 years old. The study is currently unclear on its recruitment status and plans to enroll 64 participants.

Study design
This is an interventional study involving 64 women. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Forearm blood flow is measured during the infusions to see changes from baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06520982

Early Neurovascular Adaptations in Aging Women

Recruiting
EARLY_PHASE1Ages 18–70InterventionalBasic science
University of Missouri-Columbia
~64 participants
Updated 2025-11-26 on ClinicalTrials.gov
What's tested:NorepinephrineIsoproterenolAcetylcholineNitroprussideEstrogen

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Magnitude of forearm blood flow
Measured over Change from baseline during infusion
Women
Sympathetic Nervous System
Aging
Blood Flow
1 sites across 1 states
Missouri1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Assigned female at birth (AFAB)
18-70 years of age

Exclusion

Assigned male at birth (AMAB)
Pregnancy, breastfeeding
Body mass index ≥30 kg/m2
Taking medications known to affect metabolic, autonomic, and/or respiratory function
Oral hormonal contraception in last 6 month
History of hormone replacement therapy
History of hyster- or oophor-ectomy
Current smoking/Nicotine use
Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
Chronic disease
Blood pressure ≥140/90 mmHg
Communication barriers
  • Magnitude of forearm blood flowChange from baseline during infusion