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Rehabilitative Training for Stroke Recovery

This study is looking at new ways to help people recover arm movement after a stroke. It compares two types of rehabilitative training: "Neuromuscular coordination-guided rehabilitative training" and "Force strengthening-guided rehabilitative training." Both involve using a screen to guide exercises. Researchers want to see if changing how muscles work together (intermuscular coordination) can improve arm function. They will measure changes in arm movement using standard tests like the Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT). You may be able to join if you are between 40 and 75 years old and have had a stroke. The study aims to enroll 74 participants.

Study design
This interventional study plans to enroll 74 participants. It compares two different rehabilitative training methods.
What's involved
Participants will have training sessions over 6 weeks, with assessments before training, after training, and then 1 and 3 months after the last training session.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months after the last training session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06523335

Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction

Recruiting
NAAges 40–75InterventionalTreatment
University of Houston
~74 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:Neuromuscular coordination-guided rehabilitative trainingForce strengthening-guided rehabilitative training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Fugl-Meyer Assessment (FMA) score
Measured over before any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively
+2 more outcomes measured

Conditions

Stroke

Explore related trials

Stroke

NCT06523335

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Houston

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jinsook Roh, PhD · PRINCIPAL_INVESTIGATOR · University of Houston

Who to contact

Jinsook Roh, PhD
[email protected]
7137432578
Email the study team

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Eligibility criteria

Inclusion

Male or female whose age range between 40 and 75
no known neurological injuries
male or female hemiparetic chronic stroke survivors;
age ranging between 40-75 year;
with single unilateral ischemic or hemorrhagic middle cerebral artery stroke;
neurologically stable for \>6 months;
have an expectation that current medication will be maintained without changes for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted;
without severe spasticity (Modified Ashworth (MA) \<4);
have not received botulinum toxin on the impaired arm within 3 months.

Exclusion

have an orthopedic disorder involving upper limbs;
have a history of any neurologic disease;
have any history of epilepsy of the potential participants and/or their family members;
are unable to consent;
are pregnant.
have an orthopedic disorder involving upper limbs;
cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol (Montreal Cognitive Assessment (MoCA) score \< 26);
a history of another neurologic disease;
anesthesia of joint position sense in upper limbs;
are pregnant or have a chance that they might be (self-reported);

What this trial measures

  • Change in Fugl-Meyer Assessment (FMA) scorebefore any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively

    To measure severity of motor impairment after stroke, FMA will be performed in the human upper extremity. FMA is commonly used to assess severity of motor impairment and motor recovery. The maximum FMA upper extremity motor score is 66 (i.e., 0: complete motor impairment; 66: normal motor performance). Each item is scored on a 3-point scale (0 = cannot perform, 1 = performs partially, 2 = performs fully).

  • Change in Action Research Arm Test (ARAT) scorebefore any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively

    To measure motor function after stroke, ARAT will be performed in the human upper extremity. 19 Items comprising the ARAT are categorized into four subscales (grasp, grip, pinch, and gross movement) and arranged in order of decreasing difficulty, with the most difficult task examined first, followed by the least difficult task. Task performance is rated on a 4-point scale, ranging from 0 (no movement) to 3 (movement performed normally).

  • Change in intermuscular coordination patternsbefore any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively

    EMGs will be recorded from 12 muscles. To assess whether muscle-synergy guided and/or force-guided exercise induce changes in the composition of intermuscular coordination patterns, non-negative matrix factorization will be applied to EMGs to identify and compare ICoPs. The features from EMG are muscle synergy (motor module) composition and activation profiles.