Initial Resuscitation for Acute Kidney Injury in Cirrhosis
This study is for adults hospitalized with cirrhosis (severe liver scarring) and acute kidney injury (AKI), a sudden decrease in kidney function. It aims to find the best way to give intravenous (IV) fluids to these patients. Researchers are comparing different approaches: encouraging no further fluids, giving crystalloid fluids, giving colloid fluids, or giving standard doses of IV albumin (a protein found in blood). You would be randomly assigned to a group where your medical team receives a recommendation for one of these approaches. The study will look at how much IV albumin is given, how well the medical teams follow the recommendations, and any side effects. This will help doctors understand which fluid strategy is safest and most effective.
- Study design
- This is a randomized, open-label pilot study planning to enroll 50 participants. Participants will be randomly assigned to a group where their medical team receives a specific recommendation for IV fluid treatment.
- What's involved
- You would be assessed at 48 hours after randomization, at hospital discharge, and 90 days after randomization.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed up to 90 days after randomization, or until hospital discharge, liver transplant, or initiation of RRT (renal replacement therapy, like dialysis).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- IV albumin received (grams)From date of randomization up to 48 hours
- Adherence to suggested guidanceFrom date of randomization up to 48 hours
For the VAGA group, adherence is defined as: No further resuscitation (\<500 mL total volume of IV fluid given), Resuscitation with crystalloid (\>500 mL total IV fluid given, with \<50 g IV albumin and ≤2 units blood), Resuscitation with colloid (≥50 g IV albumin or ≥2 units blood given). For the Standard of Care group, adherence is defined as receiving within 20% of the suggested IV albumin dose in grams.
- Incidence of treatment-emergent adverse events and serious adverse eventsFrom date of randomization up to hospital discharge, assessed up to 90 days