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Screening in Trauma for Opioid Misuse Prevention

This study is looking at ways to prevent opioid misuse and opioid use disorder in people who have been hospitalized for a traumatic injury. Researchers want to see if different approaches to care coordination and pain coping skills training can help. The study will test several interventions: Opioid Risk Monitoring (ORM), enhanced Trauma Care Coordination (eTCC), Pain Coping Skills Training - Brief (PCST-LITE), and Pain Coping Skills Training - Plus (PCST+). You might also receive standard Trauma Care Coordination (sTCC), which is like usual care. This study aims to find out if these interventions are practical to deliver and helpful for patients. You could be eligible if you are between 18 and 65 years old, can speak and read English, and were admitted to the hospital for a traumatic injury.

Study design
This is a pilot, randomized study involving approximately 107 participants. Participants will be assigned to one of four initial intervention groups.
What's involved
You can expect to be on the study for up to 6 months. Interventions like PCST-LITE involve a single 55-minute videoconference session, and PCST+ involves additional sessions.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 18 months to measure study progress, and for 4 and 12 weeks to track participant retention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06527599

Screening in Trauma for Opioid Misuse Prevention - an Adaptive Intervention

Active, Not Recruiting
NAAges 18–65InterventionalTreatment
University of Wisconsin, Madison
~118 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Opioid Risk Monitoring (ORM)enhanced Trauma Care Coordination (eTCC)Pain Coping Skills Training - Brief (PCST-LITE)Standard Trauma Care Coordination (sTCC)Pain Coping Skills Training - Plus (PCST+)Pain Coping Skills Training - Maintenance (PCST-M)

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent of Target Sample Size Accrued by Study Completion
Measured over up to 18 months
+3 more outcomes measured

Conditions

Opioid Misuse
Trauma Injury

Explore related trials

InjuryOpioid Misuse

Where it's being run

2 sites across 1 states
Wisconsin2

Study leadership

  • Randy Brown, MD, PhD · PRINCIPAL_INVESTIGATOR · UW School of Medicine and Public Health

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to speak, read, and write fluently in English.
Admission to site hospital for a traumatic injury at time of screening. A traumatic injury is defined as a physical injury with sudden onset requiring immediate medical attention.
Injury severity score of 9 or greater.
Meets at least one of the following descriptions below:
Received 40 mg morphine milligram equivalent (MME) within 48 hours of pre-screening; or
Discharged with a prescription for an opioid medication.
Expected to be in control of their own medications at the time of discharge from the controlled environment of hospital or short-term rehabilitation.

Exclusion

Inability to provide written consent for any reason.
Current self-reported diagnosis of cancer with life expectancy less than 12 months at time of screening.
Current prescription for opioid use disorder (e.g., suboxone, buprenorphine, methadone, naltrexone), with a current diagnosis of opioid use disorder (OUD) (mild or greater) not in remission.
History of dementing illnesses and other neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, or vascular dementia.
Current significant traumatic brain injury (defined as the presence of any intracranial blood on Computed Tomography scan of the head or best Glasgow Coma Scale Score of less than 13 at the time of screening).
Current spinal cord injury with persistent neurologic deficit at the time of screening.
Acute stroke immediately prior to/upon admission, or emergent stroke as a new event during hospitalization.
Any vision or hearing impairments resulting in an inability to complete study procedures.
Current pregnancy, as indicated by chart review and self-report.
Involved in any criminal justice proceedings related to illicit substance use at time of screening.
Incarcerated or in police custody at time of study enrollment.
Admitted to the hospital with a burn affecting \>10% total body surface area, as indicated by chart review.
Any medical, physical, cognitive, or psychiatric conditions that would limit the participant's ability to provide informed consent or complete study procedures, as determined by study staff and/or investigators.

What this trial measures

  • Percent of Target Sample Size Accrued by Study Completionup to 18 months

    A feasibility goal is to accrue at least 70 percent of the targeted sample size by study completion.

  • Number of Participants Enrolledbaseline to 4 weeks, baseline to 12 weeks

    Number of participants who enrolled

  • Number of Participants Retained4 weeks, 12 weeks

    Number of participants who completed the study

  • Acceptability of intervention12 weeks

    Participants will complete a qualitative interview regarding their experiences in the study. Responses may be used to guide future related studies.