Chicory Inulin and Gut Microbiota Study

This study is looking at how a prebiotic supplement called native chicory inulin affects the good bacteria in your gut, specifically *Bifidobacterium*. Researchers want to see how quickly and how much these bacteria change when you take inulin, and what happens to them after you stop. You might be able to join if you are a healthy adult between 18 and 45 years old with a healthy weight and regular bowel movements. Participants will take either 12 grams of inulin or 6 grams of maltodextrin (a control substance) daily. The main goal is to measure changes in *Bifidobacterium* in your stool after 13 weeks. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 52 healthy participants. It compares the effects of native chicory inulin to maltodextrin.
What's involved
You would take a supplement (inulin or maltodextrin) daily, split into two dosages. Stool samples will be collected to measure changes in *Bifidobacterium* counts at 13 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 13 weeks, which indicates the duration of the main observation period.

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NCT06528041

Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota

Recruiting
NAAges 18–45Interventional
Purdue University
~52 participants
Updated 2025-12-11 on ClinicalTrials.gov
What's tested:InulinMaltodextrin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in Bifidobacterium counts in stool samples
Measured over 13 weeks
Healthy
1 sites across 1 states
Indiana1
  • Stephen Lindemann, PhD · PRINCIPAL_INVESTIGATOR · Purdue University

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Eligibility criteria

Inclusion

adults aged 18-45
BMI \>18.5 - \< 30 kg/m2
Regular bowel movements (\> 4 days per week)

Exclusion

Self-reported sensitivity to FODMAPs and following a low FODMAP diet ((FODMAPS stands for fermentable oligosaccharides, disaccharides, monosaccharides and polyols).
Self-reported food allergies and sensitivities including gluten, dairy, nuts, soya and lactose etc.
Self-reported antibiotic treatment in the past 6 months.
Self-reported history of gastrointestinal disease and/or heart disease, cardiovascular, liver, and respiratory disorders, cancer and/or clinically relevant (pre) diabetes.
Self-reported to having undergone major surgery of the gastrointestinal tract, with the exception of cholecystectomy and appendectomy.
Self-reported smoking and/or self-reported drug or alcohol abuse.
Self-reported history of psychiatric and/or mood disorders including eating disorders.
Self-reported to be following a restrictive diet (i.e. ketogenic, intermittent fasting).
Pregnant and lactating women.
  • Changes in Bifidobacterium counts in stool samples13 weeks

    Bifidobacterium counts will be assessed by fluorescence in situ hybridisation - flow cytometry (FISH-FLOW) and 16S rRNA gene sequencing