OPUS-i for Improving Stroke Care in Rural Areas

This study, called OPUS-i, is looking at a new way to get stroke patients to the right hospital faster, especially in rural areas. It compares a new pre-hospital algorithm (a set of rules for emergency medical services or EMS) called OPUS-i to the usual way EMS decides where to take stroke patients. The goal is to improve how quickly patients get a treatment called endovascular therapy (EVT), which is important for certain types of severe strokes. You might be able to join if EMS thinks you're having a stroke or mini-stroke (TIA) and you are 18 years or older. The study is currently unclear on its recruitment status and plans to enroll 360 participants.

Study design
This interventional study will compare a new pre-hospital algorithm to a traditional one. It will involve 360 participants across multiple centers.
What's involved
Your individual participation in the study would last for 90 days.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, time from stroke onset to endovascular therapy, is assessed on day 0 of admission.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06530693

Optimizing the Prehospital Use of Stroke Systems of Care-Reacting to Changing Paradigms-Implementation (OPUS-i)

Recruiting
NAAges 18+InterventionalHealth services
Temple University
~360 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:OPUS-i algorithm

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time from stroke onset to endovascular therapy
Measured over From time of stroke onset to endovascular therapy, assessed on day 0 of admission
Stroke

NCT06530693

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • 3401 N Broad street

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

  • Cooper University Health

    Camden, New Jerseyno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Derek Isenberg, MD · PRINCIPAL_INVESTIGATOR · Lewis Katz School of Medicine at Temple University

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Eligibility criteria

Inclusion

Clinical impression of stroke/TIA by EMS clinicians

Exclusion

Age \< 18 years
Prisoner
  • Time from stroke onset to endovascular therapyFrom time of stroke onset to endovascular therapy, assessed on day 0 of admission

    This outcome will assess process measures for acute stroke patients