Advanced Imaging for Pulmonary Fibrosis

This study is looking at new ways to predict how pulmonary fibrosis (scarring of the lungs) will progress in people with certain types of interstitial lung disease (ILD). Researchers are testing two imaging techniques: a PET scan using [68Ga]CBP8 and an MRI using Gadoterate Meglumine. They want to see if these scans can help identify who will experience worsening lung disease over time. You may be able to join if you are between 18 and 80 years old, have chronic hypersensitivity pneumonitis, connective tissue-associated ILD, or undifferentiated ILD, and are on stable immunosuppression treatment. The study aims to enroll 60 participants. The study's success will be measured by how well these imaging methods predict the development of progressive pulmonary fibrosis over 24 months.

Study design
This interventional study plans to enroll 60 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will receive a single intravenous injection of [68Ga]CBP8 and a single intravenous injection of Gadoterate Meglumine. They will undergo combined PET and MRI scans at the beginning of the study.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 24 months to assess the development of progressive pulmonary fibrosis.

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NCT06532071

Advanced Imaging for Pulmonary Fibrosis

Recruiting
PHASE2Ages 18–80InterventionalDiagnostic
Peter Caravan
~60 participants
Updated 2026-04-22 on ClinicalTrials.gov
What's tested:[68Ga]CBP8Gadoterate Meglumine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Development of progressive pulmonary fibrosis
Measured over Up to 24 months
Pulmonary Fibrosis
1 sites across 1 states
Massachusetts1
  • Sydney Montesi, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • Development of progressive pulmonary fibrosisUp to 24 months

    Defined by the 2022 ATS guideline definition of progressive pulmonary fibrosis (PPF) which defines PPF as satisfying 2 of 3 criteria within 12 months: worsening symptoms, physiologic progression (absolute decline in FVC ≥ 5% or absolute decline in DLCO ≥ 10%), or radiologic evidence of disease progression.