Real-time Personalized Brain State-dependent TMS After Stroke

This study is testing a treatment called personalized brain state-dependent single-pulse Transcranial Magnetic Stimulation (TMS) for people who have had a stroke and still have weakness in their arm or hand. TMS uses magnetic fields to stimulate nerve cells in the brain. Researchers want to see if this personalized TMS can better activate brain connections (called the corticospinal tract) that are important for movement, compared to standard TMS. They will measure how much your arm and hand strength improves after one week. You may be able to join if you are 18 or older, have had an ischemic or hemorrhagic stroke at least six months ago, and still have some weakness in your arm or hand.

Study design
This interventional study plans to enroll 37 participants. It is testing a device-based intervention.
What's involved
You will visit the laboratory for two days of testing, separated by at least one night of sleep. On Day 1, you will provide informed consent.
Compensation
Not stated in the trial record.
Follow-up
Your arm and hand strength will be measured one week after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06533176

Real-time Personalized Brain State-dependent TMS After Stroke

Recruiting
NAAges 18+InterventionalBasic science
Sara Hussain
~37 participants
Updated 2026-02-03 on ClinicalTrials.gov
What's tested:Personalized brain state-dependent single-pulse TMS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MEP amplitudes
Measured over 1 week
+1 more outcome measured
Stroke

NCT06533176

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Iowa

    Iowa City, Iowastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

  • MEP amplitudes1 week

    Peak-to-peak MEP amplitudes elicited by single TMS pulses delivered during personalized brain activity patterns corresponding to strong corticospinal transmission and random brain activity patterns will be measured. At the individual participant level, all MEP amplitudes will be normalized to the mean MEP amplitude observed in that participant. Mean normalized MEP amplitudes will be used to calculate the percentage MEP amplitude difference between the two brain activity patterns (i.e., strong and random).

  • Upper Extremity Fugl-Meyer Assessment Scores1 week

    Scores obtained for each participant during the Upper Extremity Fugl-Meyer Assessment will be calculated. This will provide a single impairment score that will be correlated with the percentage MEP amplitude difference between brain activity patterns reflecting strong corticospinal transmission and random brain activity patterns.