Real-time Personalized Brain State-dependent TMS After Stroke
This study is testing a treatment called personalized brain state-dependent single-pulse Transcranial Magnetic Stimulation (TMS) for people who have had a stroke and still have weakness in their arm or hand. TMS uses magnetic fields to stimulate nerve cells in the brain. Researchers want to see if this personalized TMS can better activate brain connections (called the corticospinal tract) that are important for movement, compared to standard TMS. They will measure how much your arm and hand strength improves after one week. You may be able to join if you are 18 or older, have had an ischemic or hemorrhagic stroke at least six months ago, and still have some weakness in your arm or hand.
- Study design
- This interventional study plans to enroll 37 participants. It is testing a device-based intervention.
- What's involved
- You will visit the laboratory for two days of testing, separated by at least one night of sleep. On Day 1, you will provide informed consent.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your arm and hand strength will be measured one week after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Real-time Personalized Brain State-dependent TMS After Stroke
At a glance
Conditions
NCT06533176
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Iowa
Iowa City, Iowastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- MEP amplitudes1 week
Peak-to-peak MEP amplitudes elicited by single TMS pulses delivered during personalized brain activity patterns corresponding to strong corticospinal transmission and random brain activity patterns will be measured. At the individual participant level, all MEP amplitudes will be normalized to the mean MEP amplitude observed in that participant. Mean normalized MEP amplitudes will be used to calculate the percentage MEP amplitude difference between the two brain activity patterns (i.e., strong and random).
- Upper Extremity Fugl-Meyer Assessment Scores1 week
Scores obtained for each participant during the Upper Extremity Fugl-Meyer Assessment will be calculated. This will provide a single impairment score that will be correlated with the percentage MEP amplitude difference between brain activity patterns reflecting strong corticospinal transmission and random brain activity patterns.