Observational Study of Abbreviated MRE for Crohn's Disease

This study is looking at a new, shorter way to perform a Magnetic Resonance Enterography (MRE) scan, which is a special type of MRI that looks at your bowel. The goal is to see if this abbreviated MRE can detect active inflammation and other issues in people with Crohn's Disease as well as the standard, longer MRE. You might be able to join if you are 10 years or older, have a confirmed diagnosis of Crohn's Disease, and are already scheduled for a clinical MRE for reasons like checking inflammation or evaluating narrowing or fistulas. The study aims to compare the results of the clinical MRE with the research MRE over three years. The current recruitment status is unclear.

Study design
This is an observational study with a planned enrollment of 300 participants. It compares a clinical MRE to a research MRE.
What's involved
You would undergo an abbreviated MRE imaging test, which takes about 15 minutes. This test uses water instead of oral contrast and does not involve IV contrast or glucagon injections.
Compensation
Not stated in the trial record.
Follow-up
The primary comparison between the clinical MRE and research MRE will be measured at 3 years.

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NCT06533228

Helmsley 3.0: Abbreviated MRE

Recruiting
Not specifiedAges 10+Observational
Children's Hospital Medical Center, Cincinnati
~300 participants
Updated 2025-10-27 on ClinicalTrials.gov
What's tested:Magnetic Resonance Imaging (MRI) or Magnetic Resonance Enterography (MRE)

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Compare clinical MRE with research MRE
Measured over 3 years
Crohn's Disease
2 sites across 2 states
Minnesota1
New York1
  • Jonathan Dillman · PRINCIPAL_INVESTIGATOR · CCHMC

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Eligibility criteria

Inclusion

Established Crohn's disease diagnosis in patients 10 and older
Undergoing clinical magnetic resonance enterography (MRE) examinations for any reason(s) below
Staging/ restaging/ follow- up of intestinal inflammation
Evaluation of known or suspected luminal narrowing/ stricturing disease
Evaluation of known or suspected internal penetrating disease

Exclusion

Undergoing initial imaging for suspected Crohn's disease where the diagnosis of Crohn's disease has yet to be definitively established
New Crohn's disease diagnosis, undergoing baseline imaging
Isolated colonic disease
Known or suspected pregnancy
Contraindication to magnetic resonance imaging (MRI)
Ileostomy or prior ileal resection
Less than 10 years of age
Unable or unwilling to follow imaging procedures
Non- English speaking
  • Compare clinical MRE with research MRE3 years

    Our abbreviated magnetic resonance enterography (MRE) will be non-inferior to a standard clinical MRE in detecting small bowel inflammation, strictures and penetrating disease associated with Crohn's Disease.