Inhaled Insulin for Gestational Diabetes

This study is looking at how two different insulin treatments affect blood sugar levels after meals in pregnant women with gestational diabetes (GDM). You would be between 18 and 40 years old, have a single pregnancy between 24-34 weeks, and currently use injected rapid-acting insulin analog (RAA) for breakfast. The study compares your usual RAA injections to an inhaled insulin called Technosphere Insulin (Afrezza). You'll come to the clinic for two meal sessions. For one meal, you'll use RAA, and for the other, you'll use Afrezza. The main goal is to see which insulin better controls your blood sugar for up to two hours after eating. The study aims to enroll 30 participants, but its current status is unclear.

Study design
This is an interventional study comparing two insulin treatments in 30 pregnant women. Participants will be randomly assigned to receive either inhaled Technosphere Insulin (Afrezza) or rapid-acting insulin analog (RAA) for their first study meal, then switch to the other for their second meal.
What's involved
You would attend two clinic visits for meal sessions, where your blood sugar levels will be monitored after eating.
Compensation
Not stated in the trial record.
Follow-up
Blood sugar levels will be measured for up to 120 minutes (2 hours) after each meal.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06535789

Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes

Recruiting
PHASE2Ages 18–40InterventionalTreatment
Jaeb Center for Health Research
~30 participants
Updated 2025-05-15 on ClinicalTrials.gov
What's tested:Inhaled Technosphere Insulin

At a glance

Recruiting sites
5 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Post-prandial AUC120
Measured over 3 hours from start of meal
Diabetes, Gestational
Pregnancy Complications
Glucose Metabolism Disorders
Glucose Intolerance During Pregnancy
5 sites across 5 states
California1
Colorado1
New York1
Oregon1
Pennsylvania1
  • Amy Valent, DO · STUDY_CHAIR · Oregon Health and Science University

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  • Post-prandial AUC1203 hours from start of meal

    3-hour post-prandial (PP) area under the curve \>120 mg/dL (AUC120)