Folate Study in Men With Advanced Prostate Cancer

This study is looking at whether Trimethoprim Tablets, a drug taken once daily for 3 months, is a safe and effective way to lower folate levels in men with advanced prostate cancer who are also receiving Androgen Deprivation Therapy (ADT). Researchers want to understand the good and bad effects of Trimethoprim and how it impacts the disease. The study aims to enroll 50 men aged 18 or older who have a proven diagnosis of prostate cancer. The main goal is to check the safety of Trimethoprim. This study is currently unclear about its recruitment status.

Study design
This is an interventional study planning to enroll 50 participants. The phase of the study is not specified.
What's involved
You will attend approximately 4 to 7 visits, depending on your assigned group. These research procedures will be done during your routine hospital/clinic visits, which may be every 1-3 months. You will need to stop taking any supplements or medications with folic acid or potassium before joining.
Compensation
Not stated in the trial record.
Follow-up
Safety will be measured from the first dose through 1 month after you finish study therapy.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06536374

Folate Study in Men With Advanced Prostate Cancer

Not Yet Recruiting
PHASE2Ages 18+InterventionalTreatment
University of California, San Diego
~50 participants
Updated 2025-11-12 on ClinicalTrials.gov
What's tested:Trimethoprim Tablets

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety of Trimethoprim
Measured over From first dose of study therapy through 1 month after completion of study therapy.
Prostate Cancer
1 sites across 1 states
California1
  • Michael A Liss, MD, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Diego

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  • Safety of TrimethoprimFrom first dose of study therapy through 1 month after completion of study therapy.

    Proportion of participants with adverse events and serious adverse events as graded by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE).