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Observational Study on Bone Marrow Function in MBL and CLL

This observational study is looking at how Monoclonal B-Cell Lymphocytosis (MBL) and Chronic Lymphocytic Leukemia (CLL) affect your bone marrow's ability to fight infections. Researchers want to understand the cellular and mechanistic basis of bone marrow dysfunction in people with untreated MBL and CLL. They will also investigate if products from MBL and CLL B cells directly change how your blood-forming stem cells work. This study aims to enroll about 50 participants, including those with MBL, CLL (untreated, treated, or currently being treated), and healthy individuals who are similar in age. The main goal is to see the effects of MBL and CLL on bone marrow function at the beginning of the study.

Study design
This is an observational study planning to enroll about 50 participants. It is not testing a new treatment but rather observing how certain conditions affect the body.
What's involved
If you participate, you will have blood samples collected, undergo a bone marrow aspiration and biopsy, and your medical records will be reviewed.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, which measure the effects of MBL and CLL on bone marrow function, are assessed at Baseline (the start of the study).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06536452

Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

Recruiting
Not specifiedAges 40+Observational
Mayo Clinic
~50 participants
Updated 2026-03-31 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effects of MBL on bone marrow function
Measured over Baseline
+1 more outcome measured

Conditions

Chronic Lymphocytic Leukemia
Monoclonal B-Cell Lymphocytosis

Explore related trials

Chronic Lymphocytic LeukemiaMonoclonal B-Cell Lymphocytosis

NCT06536452

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Mayo Clinic in Rochester

    Rochester, Minnesotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Neil E. Kay, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic in Rochester

Who to contact

Clinical Trials Referral Office
[email protected]
855-776-0015
Email the study team

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Eligibility criteria

Inclusion

Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who
Remain untreated
Are currently being treated
Who have already been treated
Subjects in the MBL cohort will have a clinically established diagnosis of MBL
Healthy age-matched control subjects
Healthy younger control subjects aged \> 40 years

Exclusion

Anyone under 40
Healthy control subjects must not have a diagnosis of CLL or MBL

What this trial measures

  • Effects of MBL on bone marrow functionBaseline

    Samples collected from healthy participants and participants with MBL will be compared for differences in bone marrow function (i.e., ability to fight off infection). Results will be descriptive. With participant permission, samples will be stored for future research use.

  • Effects of CLL on bone marrow functionBaseline

    Samples collected from healthy participants and participants with CLL will be compared for differences in bone marrow function (i.e., ability to fight off infection). Results will be descriptive. With participant permission, samples will be stored for future research use.