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Methadone for Pain After Hysterectomy

This study is looking at whether a single dose of methadone given during laparoscopic (minimally invasive) hysterectomy can help reduce the amount of opioid pain medication needed afterward. Doctors are trying to find better ways to manage pain after surgery and reduce the risk of opioid abuse. You might be able to join if you are a woman, 18 or older, having a laparoscopic hysterectomy for a non-cancerous condition, and do not have chronic pain. The main goal is to see how much opioid pain medication, measured in oral morphine milligram equivalents (MME), you need in the first week after surgery. The study aims to enroll 100 participants. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 100 women. It is not specified if participants will be randomly assigned to groups or if the study is blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your total post-operative opioid requirements will be measured at 1 week after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06536517

The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.

Recruiting
PHASE2Ages 18+InterventionalTreatment
Johns Hopkins University
~100 participants
Updated 2026-01-12 on ClinicalTrials.gov
What's tested:Methadone

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total post-operative opioid requirements in oral morphine milligram equivalents (MME)
Measured over 1 week

Conditions

Fibroid Uterus

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HysterectomyUterine Corpus Leiomyoma

NCT06536517

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • The Johns Hopkins Bayview Medical Center

    Baltimore, Marylandno site contact published

    Recruiting

  • The Johns Hopkins Hospital

    Baltimore, Marylandno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Mostafa Borahay, MD, MBA, PhD · PRINCIPAL_INVESTIGATOR · Study Principal Investigator

Who to contact

Mostafa Borahay, MD, MBA, PhD
[email protected]
410-550-0337
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Individuals with a uterus
Age 18 years old and above
Undergoing minimally invasive (laparoscopic or robotic) hysterectomy with ovarian preservation
Benign indications for hysterectomy
Agreeing to participate

Exclusion

Chronic pain syndromes patients including fibromyalgia
Patients currently on long-term (i.e. for more than three months) opioid use
Patients currently on agonist-antagonist medications (e.g. buprenorphine)
Patients taking a selective serotonin reuptake inhibitor or monoamine oxidase inhibitor
Conversion to laparotomy
Allergy or other contraindication to the prescribed medications such as methadone, fentanyl, acetaminophen or oxycodone
Severe Obstructive Sleep Apnea (OSA)
Pregnant/breastfeeding patients

What this trial measures

  • Total post-operative opioid requirements in oral morphine milligram equivalents (MME)1 week

    Total post-operative opioid requirements in oral morphine milligram equivalents (MME) in first 7 post operative days.