Transcranial Magnetic Stimulation for Alzheimer's Disease and Mild Cognitive Impairment

This study is exploring how a non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS) affects memory and brain function. rTMS uses magnetic pulses to gently change activity in a part of your brain involved in memory. We want to see if rTMS can help people with Alzheimer's disease, mild cognitive impairment (a condition where memory problems are more noticeable than normal aging), or logopenic progressive aphasia (a type of dementia affecting language). You would receive both active rTMS and a sham (inactive) rTMS over two separate 10-day periods. We will measure changes in your memory and how your brain networks connect using tests and MRI scans. We are looking for about 30 participants between 40 and 99 years old who are native English speakers.

Study design
This interventional study plans to enroll 30 participants. All participants will receive both active rTMS and sham rTMS.
What's involved
You would have one initial visit, followed by 10 daily rTMS sessions (Monday through Friday), and then a final evaluation visit.
Compensation
Not stated in the trial record.
Follow-up
Your memory and brain connectivity will be measured at baseline and again on Day 11 after treatment.

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NCT06538311

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Recruiting
EARLY_PHASE1Ages 40–99Interventional
Massachusetts General Hospital
~30 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Active rTMSSham rTMS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in Memory
Measured over Baseline and post-treatment Day 11
+1 more outcome measured
Alzheimer Disease
Mild Cognitive Impairment
Logopenic Progressive Aphasia
Amnestic Symptoms
1 sites across 1 states
Massachusetts1

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  • Changes in MemoryBaseline and post-treatment Day 11

    This will include observed changes in memory as a result of the stimulation through neuropsychological testing.

  • Changes in Brain Network ConnectivityBaseline and post-treatment Day 11

    This will include observed changes in resting-state functional connectivity as a result of the stimulation.