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Portable Dynamic Chest X-Ray (DDR) in the ICU

This study is looking at a new type of chest X-ray called Portable Dynamic Digital Radiography (DDR) for patients in the intensive care unit (ICU). DDR is an advanced X-ray that takes many pictures quickly, providing more detailed information about how your lungs and diaphragm (the muscle that helps you breathe) are moving, and how blood is flowing through your lungs. This is different from traditional chest X-rays. The goal is to see if this portable DDR machine is safe and practical to use at the bedside in the ICU, and if it provides better information than current standard tests for conditions like pulmonary edema (fluid in the lungs), pneumonia, or problems after a lung transplant. We want to see how precisely it can measure lung and diaphragm movement, and blood flow. Adults aged 18 and older, who are likely to have problems with lung movement, blood flow, or fluid in their lungs, can join. The study aims to enroll 230 participants, but the current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific diagnostic test. It is planned to include 230 participants.
What's involved
Each participant will receive at least one set of Portable Dynamic Digital Radiography (DDR) images, which involves two 7-second scans.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as the precision of DDR in assessing cardiopulmonary functions, will be measured for up to 2 months.

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NCT06538376

Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU

Recruiting
NAAges 18+InterventionalDiagnostic
Brigham and Women's Hospital
~230 participants
Updated 2025-10-29 on ClinicalTrials.gov
What's tested:Portable Dynamic Digital Radiography (DDR)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
I. Extended clinical trial to study the degree of precision of the Portable DDR technology in assessing the cardiopulmonary functions of diaphragm and lung motion.
Measured over Up to 2 months
+1 more outcome measured

Conditions

Pulmonary Edema
Pneumonia
Atelectasis
Pleural Effusion
Acute Rejection of Lung Transplant (Disorder)
Airway Obstruction
Rib Fractures
Acute Copd Exacerbation
Asthma COPD
Pulmonary Embolism
Hemothorax
Pneumothorax
Mesothelioma
Diaphragmatic Paralysis

Explore related trials

Acute COPD ExacerbationAcute rejection of lung transplantAirway ObstructionAsthmaAtelectasisChronic Obstructive Pulmonary DiseaseHemothoraxMesothelial NeoplasmParalysis of diaphragmPleural EffusionPneumoniaPneumothoraxPulmonary EdemaPulmonary EmbolismRib Fracture

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Gyorgy Frendl, MD PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital
  • Hiroto Hatabu, MD PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital
  • Bruno Madore, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

Who to contact

Gyorgy Frendl, MD PhD
[email protected]
617-732-5910
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Eligibility criteria

Inclusion

Adults (at least 18 years of age) including both intubated/ventilated and non-intubated patients
Likely to have pathology related to either, abnormal diaphragmatic excursion and lung aeration, pulmonary perfusion, increased lung water content or all the above, as well as for cricopharyngeal dysfunction/swallowing difficulties at risk for aspiration.
The subject or a legally authorized representative has provided written informed consent.

Exclusion

Special populations, including women with known pregnancy, prisoners, or institutionalized individuals
Patients where additional radiation is clinically contraindicated
Care team does not provide assent for approaching patient/surrogate
For women of child-bearing potential, defined as premenopausal women, a pregnancy test will be administered to determine pregnancy status and confirm eligibility for the study. A pregnancy test will NOT be administered to women who are post-menopausal or have documentation of surgical sterilization.

What this trial measures

  • I. Extended clinical trial to study the degree of precision of the Portable DDR technology in assessing the cardiopulmonary functions of diaphragm and lung motion.Up to 2 months

    Hypothesis: The Portable DDR technology can improve the visualization of parameters associated with lung physiology for ICU patients (diaphragmatic motion, lung motion) compared to current standards of care for imaging. Aim I-1: Determine the diagnostic precision of Portable DDR technology vs. routine standard of care imaging for specific lung pathologies (for example in pre- and post-transplant patients) that affect the mentioned cardiopulmonary functions. The DDR's precision will be measured by using the most relevant diagnostic procedure, the gold standard, for the condition will be used as reference to assess both qualitative and semiquantitative or quantitative information yielded by both types of imaging. The golden standard images for each of these parameters are: 1\. Diaphragmatic/Lung motion: Ultrasound imaging.

  • II. Extended clinical trial to study the degree of precision of the Portable DDR technology in assessing the cardiopulmonary functions of pulmonary blood flow.Up to 2 months

    Hypothesis: The Portable DDR technology can improve the visualization of parameters associated with lung physiology for ICU patients (pulmonary blood flow) compared to current standards of care for imaging. Aim II-1: Determine the diagnostic precision of Portable DDR technology vs. routine standard of care imaging for specific lung pathologies (for example in pre- and post-transplant patients) that affect the mentioned cardiopulmonary function. The DDR's precision will be measured by using the most relevant diagnostic procedure, the gold standard, for the condition will be used as reference to assess both qualitative and semiquantitative or quantitative information yielded by both types of imaging. The golden standard image for this parameter is: 1\. Pulmonary blood flow: VQ scan or pulmonary angiograms The comparisons in precision for both diaphragm/lung motion and pulmonary blood flow will be aggregated to determine overall precision of the DDR technology