Ketorolac Levels in Eye Fluid During Cataract and Vitrectomy Surgery

This study is looking at how much ketorolac, a medication to reduce inflammation, gets into your eye fluids (vitreous and aqueous humor) during combined cataract and vitrectomy surgeries. Researchers want to see if there's a difference in ketorolac levels when it's given as an injection during surgery (OMIDRIA) compared to eye drops (TORADOL) given before surgery. This information can help doctors understand how well these medications work to prevent inflammation after eye surgery. You may be able to join if you are an adult needing both cataract surgery and a vitrectomy for conditions like an epiretinal membrane or macular hole.

Study design
This interventional study plans to enroll 10-20 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo combined cataract surgery and pars plana vitrectomy. Eye fluid samples will be taken during your surgery for analysis.
Compensation
Not stated in the trial record.
Follow-up
Ketorolac concentration in the vitreous humor will be measured on the day of surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06539637

Ketorolac Levels in Vitreous and Aqueous Samples From Patients Undergoing Combined Cataract and Pars Plana Vitrectomy Surgeries With and Without Intracameral Phenylephrine 1.0% / Ketorolac 0.3%

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
DHS Consulting
~20 participants
Updated 2024-08-06 on ClinicalTrials.gov
What's tested:OMIDRIA (*Registered Product) {10.16 mg/mL (1% w/v) of phenylephrine and 2.88 mg/mL (0.3% w/v) of ketorolac}Ketorolac Tromethamine {TORADOL} (0.5%) - Topical Eyedrop

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Concentration of ketorolac in the vitreous humor
Measured over The day of surgery
Cataract
1 sites across 1 states
New York1
  • Eric Donnenfeld, MD · PRINCIPAL_INVESTIGATOR · Ophthalmic Consultants of Long Island

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  • Concentration of ketorolac in the vitreous humorThe day of surgery

    Vitreous samples taken from vitrectomy at the beginning of the procedure for all patients.