Understanding Pain Relief After Wisdom Tooth Extraction

This study is looking at why some people need opioid pain medicine after having their wisdom teeth removed, even when they take ibuprofen. Ibuprofen is a common pain reliever (a nonsteroidal anti-inflammatory drug or NSAID) often recommended first for dental pain. Researchers want to find out what factors lead to needing extra pain relief, like opioids, after this surgery. The goal is to help doctors prescribe fewer unnecessary opioids, which can contribute to addiction. You might be able to join if you are an adult, at least 18 years old, and need to have at least one impacted wisdom tooth removed. The study will measure how much opioid pain medicine you use for up to 7 days after your surgery. The current status of this observational study is unclear, and it plans to include about 200 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without giving you a specific treatment. It plans to include about 200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your use of supplemental opioid pain medicine will be measured for up to 7 days after your wisdom tooth extraction.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06539741

Variability in Analgesic Response to Ibuprofen

Recruiting
Not specifiedAges 18+Observational
University of Pennsylvania
~200 participants
Updated 2026-05-06 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Supplemental Opioid Use
Measured over Up to 7 days after third molar extraction
Impacted Third Molar Tooth
Pain, Acute
1 sites across 1 states
Pennsylvania1
  • Katherine N Theken, PharmD, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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  • Supplemental Opioid UseUp to 7 days after third molar extraction

    Use of oxycodone in addition to ibuprofen + acetaminophen