Ketogenic Diet and Brain Response in Anorexia Nervosa

This study is looking at how a Therapeutic Ketogenic Diet (TKD) affects the brain in people who have recovered from anorexia nervosa (AN). The study will involve a 2-week period to start the ketogenic diet, followed by 12 weeks on the diet. Researchers want to see if the diet changes how the brain uses sugar, which they will measure using special brain scans called [18F]fluorodeoxyglucose (FDG) uptake scans. You might be able to join if you are 18-45 years old, male or female, and have recovered your weight after having restricting-type anorexia nervosa. The study is currently unclear on its recruitment status.

Study design
This is a longitudinal study with an open design, meaning participants and researchers will know what treatment is being given. It plans to enroll 90 participants, including those who have recovered from anorexia nervosa and healthy controls.
What's involved
Participants will have brain scans before and after the 14-week Therapeutic Ketogenic Diet. They will also complete questionnaires about eating behaviors.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for six months after the intervention.

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NCT06540703

Ketogenic Diet and Brain Response in Anorexia Nervosa

Recruiting
NAAges 18–45InterventionalTreatment
University of California, San Diego
~90 participants
Updated 2026-04-23 on ClinicalTrials.gov
What's tested:Therapeutic Ketogenic Diet (TKD)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
[18F]fluorodeoxyglucose (FDG) uptake
Measured over Difference in pre/post Therapeutic Ketogenic Diet PET/CT scans
Anorexia Nervosa
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Age 18-45 years old
Male and Female sexes
All ethnic backgrounds
History of restricting-type anorexia nervosa (AN) according to DSM-5 criteria
Weight recovered with a body mass index \> 17.5 for at least one month at the time of study
Elevated eating disorder-relevant behaviors on the Eating Disorders Inventory-3 and the Eating Disorder Examination Questionnaire
Age 18-45 years old
Male and Female sexes
All ethnic backgrounds
Normal lifetime BMI according to CDC

Exclusion

Current pregnancy or nursing (will have to agree to contraceptive measures if sexually active)
Lifetime history of bipolar I disorder or psychosis
Current substance abuse or dependence in the past 3 months
Psychotic illness/other organic brain syndromes, dementia, somatization disorders or conversion disorders
History of significant head trauma
Indication of intellectual disability or autism spectrum disorder
No lifetime psychiatric illness and in particular no eating disorder history
Not be taking medication, and will not have a first degree relative with an eating disorder.
mental retardation or pervasive developmental disorder
organic brain syndrome
dementia
psychotic disorder
bipolar disorder
somatic symptom
conversion disorder
current alcohol or substance use disorder
indication of major medical illness including a history of seizure disorder
pregnant or nursing at the time of the study
a history of traumatic brain injury.
diabetes mellitus or other metabolic disorders that could worsen on a ketogenic diet
intracranial or any other metal object within or near the head that cannot be safely removed, excluding the mouth
implanted neurostimulators, intracardiac lines, or heart disease
  • [18F]fluorodeoxyglucose (FDG) uptakeDifference in pre/post Therapeutic Ketogenic Diet PET/CT scans

    To test whether TKD will be associated with reduced brain \[18F\]fluorodeoxyglucose (FDG) uptake