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Study of TENS for Post-Stroke Recovery

This study is looking at how Transcutaneous Electrical Nerve Stimulation (TENS) using the InTENSity 10 TENS Stimulator might help people who have had a stroke. TENS is a portable device that sends gentle electrical currents to nerves and muscles through pads placed on the skin. We want to see if this treatment can improve reflexes, walking ability, and how well people adapt to different movements after a stroke. You might be able to join if you are between 18 and 80 years old, had a single stroke at least 6 months ago that caused weakness on one side of your body (hemiparesis), and can walk as part of your daily activities. The study is currently unclear about its recruitment status and plans to enroll 100 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 100 participants.
What's involved
You would attend a minimum of 15 separate sessions. The first session involves screening, consent, orientation, and about 3 hours of data collection. Subsequent sessions will also last approximately 3 hours.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as reflex and walking tests, will be measured at 3 months after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06541015

Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients

Recruiting
NAAges 18–80InterventionalBasic science
University of Texas Southwestern Medical Center
~100 participants
Updated 2026-03-30 on ClinicalTrials.gov
What's tested:InTENSity 10 TENS Stimulator

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reflex Testing
Measured over 3 months
+2 more outcomes measured

Conditions

Hemiplegia and/or Hemiparesis Following Stroke
Anterior Circulation Stroke of Uncertain Pathology

Explore related trials

HemiparesisHemiplegiaStroke

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Yasin Dhaher, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center

Who to contact

Yasin Dhaher, Ph.D.
[email protected]
214-645-0064
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

History of single unilateral stroke with subsequent lower limb hemiparesis on either side (\> 6 months since onset)
Ability to walk as part of activities of daily living
Age between 18 and 80
No history of stroke, cerebral palsy, injury or surgery to the lower limb.
Currently not taking any central nervous system (CNS) affecting medication.
Ability to walk as part of activities of daily living
Age between 18 and 80

Exclusion

Presence of concurrent severe medical illness including unhealed pressure sore, active or untreated infection, thromboembolic disease, severe contracture, osteoporosis, heterotropic classification, lower limb fracture, severe pulmonary disease or cardiovascular instability, uncontrolled seizure, uncontrolled diabetes
History of any neurological injury other than a single stroke
Has received a Botox injection in the lower extremity within the last 4 months
Any cognitive deficit that would prevent informed consent or ability to perform the experiment
History of prior injury or surgery to the hip or knee
Presence of significant lower extremity edema - Presence of cardiac pacemaker or any other electrically implanted device - Use of braces limiting harness/Lokomat fit (Any spinal orthoses such as TLSO, HALO)
Weight greater than 300 pounds
Adults unable to consent, infants, children, teenagers, pregnant women and prisoners will not be included in the study
Clinically significant depression, psychiatric disorders, or ongoing drug abuse
Actively taking medications with agents known to increase (e.g. amphetamines) or decrease motor system excitability
Suffered a concussion in the last 6 months.
Unexplained headaches
Presence of concurrent severe medical illness including unhealed pressure sore, active or untreated infection, thromboembolic disease, severe contracture, osteoporosis, heterotropic classification, lower limb fracture, severe pulmonary disease or cardiovascular instability, uncontrolled seizure, uncontrolled diabetes
History of any neurological injury
Taking any medication affecting change in CNS
Any cognitive deficit that would prevent informed consent or ability to perform the experiment
History of prior injury or surgery to the hip or knee
Presence of significant lower extremity edema - Presence of cardiac pacemaker or any other electrically implanted device - Use of braces limiting harness/Lokomat fit (Any spinal orthoses such as TLSO, HALO)
Weight greater than 300 pounds
Adults unable to consent, infants, children, teenagers, pregnant women and prisoners will not be included in the study
Clinically significant depression, psychiatric disorders, or ongoing drug abuse
Actively taking medications with agents known to increase (e.g. amphetamines) or decrease motor system excitability
Suffered a concussion in the last 6 months.
Unexplained headaches
Has received a Botox injection in the lower extremity within the last 4 months

What this trial measures

  • Reflex Testing3 months

    Test if tsDCS (transcutaneous spinal direct current stimulation) has any beneficial effect on reflexes in post-stroke individuals

  • Walking Testing3 months

    Test if tsDCS (transcutaneous spinal direct current stimulation) has any beneficial effect on walking in post-stroke individuals

  • Adaptation Testing3 months

    Test if tsDCS (transcutaneous spinal direct current stimulation) has any beneficial effect on adaptation pattern in post-stroke individuals