Azithromycin Before Induction for Infection Prevention

This study is testing if taking a single dose of azithromycin (an antibiotic) before starting labor induction can lower your risk of getting an infection during or after delivery. You might be able to join if you are 18-45 years old, in your third trimester (28 weeks or more pregnant) with a single baby, and planning to have your labor induced. Half of the participants will receive azithromycin, and the other half will receive a placebo (inactive pill). Researchers will compare infection rates at delivery and six weeks postpartum to see if azithromycin helps. The study aims to enroll 400 participants, but its current recruitment status is unclear.

Study design
This is a double-blinded, randomized controlled trial, meaning neither you nor your doctors will know if you receive azithromycin or a placebo. The study plans to include 400 participants.
What's involved
You would receive either azithromycin or a placebo pill before your labor induction begins.
Compensation
Not stated in the trial record.
Follow-up
Your infection status will be checked at delivery and again six weeks after you give birth.

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NCT06543290

Azithromycin Before Induction

Recruiting
PHASE1Ages 18–45InterventionalPrevention
Arrowhead Regional Medical Center
~400 participants
Updated 2025-09-12 on ClinicalTrials.gov
What's tested:Azithromycin PillPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Composite Infection
Measured over Delivery and 6 weeks postpartum
Infections
1 sites across 1 states
California1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

• Third trimester of pregnancy defined as 28 0/7 weeks or more
Singleton pregnancy
Age 18-45
Induction of labor initiated for medical or obstetrical reason or electively over 39 weeks of gestation
No contraindication to vaginal delivery
Reassuring fetal heart rate tracing
Able and willing to provide informed consent

Exclusion

• Does not read or write in English or Spanish
Unable or unwilling to give informed consent
Use of antibiotic or antiviral agent within the last 7 days
Evidence of active infection at the time of initiation of induction (patients with rectovaginal group B streptococcus positive results will be allowed to participate as it is a colonizing organism, unless they show evidence of active infection)
Incarcerated Women
Active substance abuse
Age \< 18
  • Change in Composite InfectionDelivery and 6 weeks postpartum

    single oral dose of Azithromycin given prior to the start of induction of labor will decrease rates of composite infection