This study is looking at how a combination of THC (delta-9-tetrahydrocannabinol) and CBD (cannabidiol) might help people who have both chronic pain and opioid use disorder (OUD). Researchers want to see if these combined substances can reduce pain and lessen the craving for opioids in people who are also receiving methadone therapy. You might be able to join if you are between 18 and 65 years old, have both chronic pain and OUD, and are currently on methadone treatment. The study will test different doses of CBD (300mg or 600mg) and THC (5mg, 10mg, or placebo) to see which combinations are most effective. The main goals are to measure changes in your pain sensitivity and opioid craving.

Study design

This is a Phase 2 study with 147 participants. It uses a double-blind, placebo-controlled, crossover design, meaning neither you nor the study staff will know which treatment you are receiving, and you will try different treatments over time.

What's involved

You will participate in three test sessions where you will receive different doses of CBD, THC, or a placebo. Pain sensitivity will be measured for up to 8 hours, and opioid craving will be measured at the start and 180 minutes after your dose.

Compensation

Not stated in the trial record.

Follow-up

Pain sensitivity will be measured for up to 8 hours after a dose. Opioid craving will be measured at baseline and 180 minutes after a dose.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.