This study is looking at how well a treatment called Leukocyte and Platelet Rich Fibrin (L-PRF) helps healing after a type of dental surgery called endodontic microsurgery. L-PRF is made from your own blood and contains special cells that help repair tissue. You might be able to join if you are an adult with a persistent infection around the root of your tooth (apical periodontitis) and are already scheduled for endodontic microsurgery at the University of Pennsylvania School of Dental Medicine. The study will check how well your tooth heals over 12 and 24 months. The current recruitment status is unclear.

Study design

This is an observational study planning to enroll 50 participants. It is not specified if the study is randomized or blinded.

What's involved

If you join, you will have L-PRF placed during your routine endodontic microsurgery. Your healing will be checked with X-rays and exams at 6, 12, 18, and 24 months.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 24 months after the surgery to assess healing.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.