Glucose Monitoring in Youth With Cystic Fibrosis During Pulmonary Exacerbations

This study is looking at how blood sugar levels change in young people (ages 6-25) with cystic fibrosis (CF) when they have a pulmonary exacerbation (PEx), which is a flare-up of their lung symptoms. Researchers will use continuous glucose monitoring (CGM) to track blood sugar changes during these flare-ups, whether you're in the hospital or seen in the clinic. The goal is to see if blood sugar changes are greater during a PEx compared to when you're feeling better, and if these changes are linked to how you're feeling and if you need more antibiotics. This is an observational study, meaning no specific interventions are being tested. The study plans to enroll 50 participants and is currently unclear on its recruitment status.

Study design
This is an observational study that plans to enroll 50 participants. It will look at changes in blood sugar levels over time.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Blood sugar changes will be measured at 14 days after a pulmonary exacerbation.

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NCT06546943

Glucose Monitoring in Youth With Cystic Fibrosis During Pulmonary Exacerbations

Recruiting
Not specifiedAges 6–25Observational
University of Colorado, Denver
~50 participants
Updated 2024-08-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
CGM standard deviation
Measured over 14 days
+2 more outcomes measured
Cystic Fibrosis Pulmonary Exacerbation
1 sites across 1 states
Colorado1

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Eligibility criteria

Inclusion

6- 25 years old
Confirmed diagnosis of cystic fibrosis (based on sweat chloride and/or two known disease causing CF mutations)
access to a smart phone and/or internet connection and the ability to complete remote telehealth visits

Exclusion

known type 1 or type 2 diabetes, monogenic diabetes
critical illness requiring admission to the ICU
pregnancy
  • CGM standard deviation14 days

    Measures of glycemic variability from CGM during the exacerbation (CGM-PEx) compared measure derived from recovery period (CGM-post)

  • CGM coefficient of variation14 days

    CGM measure of glycemic variability during the exacerbation (CGM-PEx) with recovery measure (CGM-post)

  • MAGE (mean amplitude of glycemic excursions)14 days

    CGM measures of glycemic variability (MAGE) during the exacerbation (CGM-PEx) with recovery measures (CGM-post)