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Thrombosis and Inflammation in Vessels Initiative (TIVI)

This study, called TIVI, aims to understand more about diseases involving the immune system, blood clots (thrombosis), and blood vessels. These conditions can affect many parts of the body, and researchers want to learn how they start, how they change over time, and how they impact different organs like the heart and brain. The study is looking for people aged 5 and older who have a disease related to blood clots, the immune system, or blood vessels. Healthy relatives of people with these diseases and healthy volunteers are also needed. There are no specific treatments being tested in this study; instead, it's focused on gathering information to help design future studies and improve understanding of these conditions.

Study design
This is an observational study, meaning no specific intervention is given. It plans to enroll 1000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06552767

Thrombosis and Inflammation in Vessels Initiative (TIVI)

Recruiting
Not specifiedAges 5+Observational
National Heart, Lung, and Blood Institute (NHLBI)
~1,000 participants
Updated 2026-08-19 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
This is a disease discovery protocol and there are no specific endpoints associated with this protocol.
Measured over Study End

Conditions

Cardiovascular Diseases
Vascular Diseases

Explore related trials

Cardiovascular DisorderImmune System DisorderThrombotic DisorderVascular Disorder

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Yogendra Kanthi, M.D. · PRINCIPAL_INVESTIGATOR · National Heart, Lung, and Blood Institute (NHLBI)

Who to contact

Jessenia C Campos, R.N.
[email protected]
(301) 402-0300
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age \>= 5 years at the time of consent
Ability of subject or Legally Authorized Representative (LAR) as applicable to understand and the willingness to sign a written informed consent document
Known or possible thrombotic, immune, or vascular disorder after review of the subject s medical records and/or discussion of medical history
Being a relative of an affected subject
In good general health as evidenced by medical history

Exclusion

Any condition that in the opinion of the Investigator would warrant exclusion
Unrelated healthy volunteers who decline to have blood drawn and/or tissue studies or who do not consent to have samples stored for future research
Cognitively impaired individuals

What this trial measures

  • This is a disease discovery protocol and there are no specific endpoints associated with this protocol.Study End