Home-based Cycling for Multiple Sclerosis and High Blood Pressure

This study is looking at whether 12 weeks of home-based cycling exercise can improve blood pressure, thinking skills (cognition), and walking ability in people with multiple sclerosis (MS) who also have high blood pressure (hypertension). You would use a special stationary bike at home, gradually increasing your exercise time and effort. The study wants to see if this cycling can improve blood pressure by helping blood vessels widen, and if better blood pressure then helps with thinking and walking. To join, you need to be an adult (18+) with a confirmed MS diagnosis (Expanded Disability Status Scale scores of 4-6.5) and high blood pressure (systolic blood pressure > 120 mmHg or diastolic blood pressure > 80 mmHg). The study plans to enroll 80 participants, but its current status is unclear.

Study design
This is an interventional study comparing home-based aerobic training (cycling) to a home-based stretching program. It plans to enroll 80 participants.
What's involved
You would participate in a 12-week home-based cycling program, progressing from 10 to 40 minutes per session. Your information processing speed and walking ability will be measured at the beginning and within 5 days after the program ends.
Compensation
Not stated in the trial record.
Follow-up
Your information processing speed and walking ability will be measured within 5 days after completing the 12-week training intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06554340

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

Recruiting
NAAges 18+InterventionalTreatment
University of Massachusetts, Boston
~80 participants
Updated 2025-08-22 on ClinicalTrials.gov
What's tested:Home-based aerobic training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Information processing speed
Measured over Baseline, pre-intervention/BICAMS; Within 5 days after completion of the training intervention/BICAMS
+1 more outcome measured
Multiple Sclerosis
Hypertension
1 sites across 1 states
Massachusetts1
  • Bo Fernhall, PhD · PRINCIPAL_INVESTIGATOR · University of Massachusetts, Boston
  • Tracy Baynard, PhD · PRINCIPAL_INVESTIGATOR · University of Massachusetts, Boston

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;
Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \> 120 mmHg or brachial diastolic blood pressure \> 80 mmHg)
Persons who are physically inactive (less than 60 min/wk of physical activity);
Persons with body mass index \< 40 kg/m2;
Persons who are not confined to a wheel chair;
Multiple sclerosis relapse in the past 30 days;
People with stable pharmacotherapy.

Exclusion

People with additional cardiovascular comorbidities;
People with type 1 diabetes mellitus;
Physician disapproval to participating in the study;
Space constraints to fit a cycle ergometer at the home of prospective participants.
  • Information processing speedBaseline, pre-intervention/BICAMS; Within 5 days after completion of the training intervention/BICAMS

    The Brief International Cognitive Assessment (BICAMS) battery tests, including the Symbol Digit Modalities Test (SDMT) and California Verbal Learning Test-II (CVLT-II)

  • Timed 25-Foot WalkBaseline, pre-intervention/25-Foot Walk; Within 5 days after completion of training intervention/ 25-Foot Walk

    Measurement of mobility disability