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MegaNatural BP® GSE for Blood Pressure and Prediabetes

This study is testing if a grape seed extract called MegaNatural BP® (150mg tablet) can help lower blood pressure and improve heart health in people with slightly high blood pressure and prediabetes. Researchers want to see if this supplement can help with how blood vessels work and reduce inflammation. You might be able to join if you are between 40 and 60 years old, have elevated blood pressure (120-140 mmHg systolic / less than 90 mmHg diastolic), and have prediabetes (fasting blood sugar between 100-125 mg/dL or HbA1c 5.7-6.4%). The main goal is to see if blood pressure changes after 6 weeks. The study is currently recruiting 80 participants.

Study design
This is an interventional study, meaning participants will receive either the MegaNatural BP® supplement or a placebo capsule. It plans to enroll 80 participants.
What's involved
You would visit the research center seven times over six weeks. These visits include screening, blood pressure monitor fittings, and four study days where blood will be collected and blood vessel flexibility measured.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes are measured at 6 weeks, which is the duration of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06555952

MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

Recruiting
NAAges 40–60InterventionalPrevention
Clinical Nutrition Research Center, Illinois Institute of Technology
~80 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:MegaNatural-BP SR 150Mg TabletPlacebo Capsule

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in change of systolic blood pressure
Measured over 6 weeks
+1 more outcome measured

Conditions

Hypertension
Pre Diabetes

Explore related trials

Diabetes typeHypertension

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Britt Burton-Freeman · PRINCIPAL_INVESTIGATOR · 708-563-8276

Who to contact

Indika Edirisinghe
[email protected]
708-563-8178
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

40-60 years of age
BMI \< 30kg/m2
elevated blood pressure 120-140 mmHg (systolic) / \<90 mmHg (diastolic) at screening visit
Has fasting blood glucose concentration between 100-125 mg/dL or HbA1c 5.7-6.4%.
Not taking any medications that would interfere with outcomes of the study, i.e. blood pressure lowering medications or anti-diabetes medications.
Able to provide informed consent
Able to comply and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary and GI tolerance questionnaire, sample collection procedures and study visit schedule)
Able to maintain usual physical activity pattern
Able to avoid / abstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit

Exclusion

Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or interventions
Men and women with diabetes or have documented liver, kidney, cardiac, gastrointestinal, metabolic or respiratory diseases.
Men and women with documented physical or mental disease/condition or major surgery as revealed by history or physical examination, which might limit participation in or completion of the study or, that, in the opinion of the investigator, could interfere with the interpretation of the study results.
Women who are known to be pregnant or who are intending to become pregnant over the course of the study
Women who are lactating
Taking medication or dietary supplements that may interfere with the outcomes of the study; This may include anti-inflammatory medication (ibuprofen, Aleve/naproxen, aspirin, etc.)
Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI.
Has used antibiotics within the previous 2 months
Had colonoscopy within 3 months
History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional
Substance (alcohol or drug) abuse within the last 2 years
Excessive coffee and tea consumers (\> 4 cups/d)
Donated blood within last 3 months
Men and women who do excessive exercise regularly or are an athlete
Unstable weight: gained or lost weight +/- 5 kg (11 lbs) in previous 2 months
Women who are taking unstable dose and brand of hormonal contraceptives and/or stable dose and brand less than 6 months
Unusual working hours i.e., working overnight (e.g. 3rd shift)
Follows a vegan diet or any extreme dietary patterns

What this trial measures

  • Difference in change of systolic blood pressure6 weeks

    After 6 weeks of 150mg GSE MegaNatural BP per day the base level blood pressure should change

  • Difference in change of diastolic blood pressure6 weeks

    After 6 weeks of 150mg GSE MegaNatural BP per day the base level blood pressure should change