Back to search results

Observational Study on Childhood Stress and Cardiovascular Health

This observational study, called "Cardiovascular Health & Early Stress," is looking at how childhood stress (also known as adverse childhood experiences or ACEs) might affect your heart and blood vessels. Researchers want to understand why experiencing difficult events as a child can lead to heart problems later in life. They will divide participants into groups based on whether they experienced adversity during childhood. The study will measure your vascular function (how well your blood vessels work) and cardiac function (how well your heart works), as well as take a cardiac MRI (a detailed picture of your heart) at the beginning of the study. This study is open to males and females aged 9 to 30 years old. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 120 participants. Participants will be divided into groups based on their childhood stress experiences.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Vascular function, cardiac function, and cardiac MRI will be measured at Baseline (the start of the study).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06557707

Cardiovascular Health & Early Stress

Recruiting
Not specifiedAges 9–30Observational
Virginia Commonwealth University
~120 participants
Updated 2025-09-04 on ClinicalTrials.gov
What's tested:Childhood stress

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Vascular function
Measured over Baseline
+2 more outcomes measured

Conditions

Stress

Explore related trials

Stress

Where it's being run

1 sites across 1 states
Virginia1

Study leadership

  • Paula Rodriguez Miguelez · PRINCIPAL_INVESTIGATOR · Virginia Commonwealth University

Who to contact

Paula Rodriguez Miguelez
[email protected]
(804) 396-4498
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Men and pre-menopausal women
18-30 years old
males and females
9-17 years old

Exclusion

Evidence of cardiovascular, pulmonary, renal, hepatic or cerebral diseases
Evidence of pregnancy or currently nursing.
Having a history of chronic pain
Having a history of rheumatoid arthritis
Evidence of cardiovascular, pulmonary, renal, hepatic or cerebral diseases
Evidence of pregnancy or currently nursing.
Having a history of chronic pain
Having a history of rheumatoid arthritis

What this trial measures

  • Vascular functionBaseline

    This test examines how the blood vessels respond to different challenges and expand. It is used to characterize the cardiovascular health of the subject's blood vessels. Different events and substances will be used (under an IND) to test how the blood vessels react. The test is completed using Laser Doppler Speckle Contrast. We will measure how much the blood vessels dilate. Greater dilation, better vascular function.

  • Cardiac FunctionBaseline

    An evaluation of cardiac response will be monitored non-invasively. We will use ultrasound to visualize the heart and the blood vessels.

  • Cardiac MRI (CMR)Baseline

    Cardiac MRI will be completed to monitor early signs of poor functionality.