Study for Diabetic Foot and Venous Leg Ulcers

This study is testing different treatments for non-healing diabetic foot ulcers (DFU) and venous leg ulcers (VLU). You might receive standard care (cleaning, debridement, moisture balance, and offloading for DFU or compression for VLU) alone, or standard care combined with AmnioCore, Amnio Quad-Core (for DFU), or Amnio Tri-Core (for VLU). Researchers want to see if these combined treatments help ulcers close completely over 12 weeks compared to standard care alone. To join, you must be at least 21 years old, have type 1 or 2 diabetes, and have a target ulcer between 1.0 and 5.0 cm² after cleaning. The current recruitment status is unclear.

Study design
This is a randomized controlled study involving 324 participants. It compares several treatments (AmnioCore, Amnio Quad-Core, Amnio Tri-Core) combined with standard care against standard care alone.
What's involved
You would receive weekly treatments for up to 13 weeks, or until your ulcer closes. This includes cleaning, debridement, and specific applications depending on your assigned group.
Compensation
Not stated in the trial record.
Follow-up
The main goal is to measure differences in ulcer closure between 1 and 12 weeks after starting treatment.

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NCT06560502

Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs

Recruiting
NAAges 21+InterventionalTreatment
Stability Biologics
~324 participants
Updated 2025-01-20 on ClinicalTrials.gov
What's tested:Standard of Care-DFUAmnioCore - DFUAmnio Quad-Core - DFUStandard of Care-VLUAmnio Tri-Core - VLUAmnioCore Pro

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determine the between-arm difference
Measured over 1-12 Weeks
Diabetic Foot Ulcer
Venous Leg Ulcer
Ulcer Foot
Leg Ulcer
1 sites across 1 states
Ohio1

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Eligibility criteria

Inclusion

1\. Subjects must be at least 21 years of age or older. 2. Subjects must have a diagnosis of type 1 or 2 Diabetes mellitus. 3. At randomization subjects must have a target ulcer with a minimum surface area of 1.0 cm2 and a maximum surface area of 5.0 cm2 measured post debridement .
  • Determine the between-arm difference1-12 Weeks

    To determine the between-arm difference in the proportion of subjects achieving complete closure of nonhealing diabetic foot ulcers and venous leg ulcers with multiple CAMPs plus SOC versus SOC alone over 12 weeks using a modified dual platform (Matriarch) trial design.