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NCT06561035

Reduce Opiate Exposure With ACL Surgery

Enrolling by Invitation
PHASE3Ages 14–85InterventionalTreatment
Campbell Clinic
~56 participants
Updated 2026-09-15 on ClinicalTrials.gov
What's tested:Opiate SparingOpiate Based

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Visual Analog Scale
Measured over Once per day from postoperative day 1 to postoperative day 14; at two weeks follow up visit, 6 weeks follow up visit and 12 weeks follow up visit.
+1 more outcome measured

Conditions

Anterior Cruciate Ligament Injuries

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NCT06561035

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Campbell Clinic

    Memphis, Tennesseeno site contact published

  • Endeavor Health

    Skokie, Illinoisno site contact published

  • University of Cincinnati

    Cincinnati, Ohiono site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Frederick Azar, MD · PRINCIPAL_INVESTIGATOR · Campbell Clinic

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

14-85 years of age.
Patients undergoing primary ACL-R with or without meniscus repair or meniscectomy, with or without chondroplasty.
Patients weigh at least 90lbs at time of enrollment.
Surgery scheduled at a Campbell Clinic Surgery Center (Midtown or Wolf River).
Willing and able to provide written informed consent.
Willing and able to cooperate with postoperative therapy.
Speak and read fluent English.

Exclusion

Multiligament knee reconstruction.
Pre-injury opioid consumption.
Substance abuse disorder (illicit drug abuse, alcoholism, etc).
Concomitant injuries or surgeries warranting pain medication (i.e. polytrauma patient).
Chronic pain syndrome.
Renal disease.
Currently taking selective serotonin reuptake inhibitors and/or serotonin and norepinephrine reuptake inhibitors.
Known sensitivity, allergy, or intolerance to medications within protocols.
History of diabetes.
Currently taking glucagon-like peptide 1 agonist.
Female patient who is pregnant on day of surgery or becomes pregnant during study period.

What this trial measures

  • Visual Analog ScaleOnce per day from postoperative day 1 to postoperative day 14; at two weeks follow up visit, 6 weeks follow up visit and 12 weeks follow up visit.

    Record pain score with 0 being no pain at all and 10 being worst pain possible.

  • Oral morphine equivalentdaily pill count from postoperative day 1 to postoperative day 14; at 2-week follow up visit, 6-week follow up visit and 12-week follow up visit.

    Opiate pill count