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Magnesium Supplementation After Pediatric Heart Surgery

This study is looking at the best way to give magnesium (MgSO4) to children after heart surgery. Children who have heart surgery, especially with a heart-lung machine (cardiopulmonary bypass), can sometimes develop kidney problems (Acute Kidney Injury or AKI) or irregular heartbeats (arrhythmia). Magnesium can help reduce these risks. This study will compare two ways of measuring magnesium in the blood – total magnesium and ionized magnesium – to see which method helps doctors give the right amount of MgSO4. The goal is to see if using ionized magnesium measurements leads to better outcomes for children. We are looking for children aged 0 to 18 years who are having heart surgery with a heart-lung machine. The study will measure how long it takes for the heart to return to a normal rhythm and how much time is spent in irregular rhythms after surgery.

Study design
This interventional study plans to enroll 96 participants. Participants will be randomly assigned to receive MgSO4 based on either total magnesium or ionized magnesium levels.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will measure heart rhythm outcomes for up to 48 hours after the heart-lung machine is removed.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06564376

Tailored MgSO4 Supplementation to Reduce Complications in Pediatric Heart Surgery

Not Yet Recruiting
NAAges 0–18InterventionalPrevention
West Virginia University
~96 participants
Updated 2026-06-16 on ClinicalTrials.gov
What's tested:total magnesiumionized magnesium

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Duration from reanimation to sinus rhythm
Measured over 48 hours after reanimation
+5 more outcomes measured

Conditions

AKI - Acute Kidney Injury
Arrythmia
Congenital Heart Disease

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NCT06564376

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • West Virginia University

    Morgantown, West Virginiano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • David A Rosen, MD · PRINCIPAL_INVESTIGATOR · West Virginia University

Who to contact

David A Rosen, MD
[email protected]
3045984000 · ext. 4122
Email the study team

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Eligibility criteria

Inclusion

Children undergoing cardiac surgery utilizing cardiopulmonary bypass

Exclusion

Children undergoing cardiac surgery without cardiopulmonary bypass
Children with Renal disease
Children with pre-existing arrhythmia
Children on anti-arrhythmia medication

What this trial measures

  • Duration from reanimation to sinus rhythm48 hours after reanimation
  • Time in non-sinus rhythms: within 24h of removing aortic cross-clampfirst 24 hours after reanimation
  • Time in non-sinus rhythms: 24-48h after removing aortic cross-clamp24-48 hours after reanimation
  • Presence of any arrhythmia48 hours after reanimation

    Defined as any non-sinus rhythm

  • Urine NGAL concentration48 hours after reanimation

    Sensitive marker of acute kidney injury

  • Urine Creatinine concentration48 hours after reanimation

    The combination of NGAL/Creatine increases sensitivity marker of acute kidney injury