ImmunoBoost: The Lymphatic Osteopathic Manipulative Treatment Protocol Study

This study, called ImmunoBoost, is looking at how different treatments affect your immune system. Researchers want to see if osteopathic manipulative treatment (OMT), which involves hands-on techniques, can make your immune system more ready to respond, compared to light touch or exercise. They will measure immune cells and signaling molecules in your blood after each treatment. You might be able to join if you are a healthy adult, 18 or older, with a body mass index (BMI) under 30, and don't have immune problems or use immune-altering medications. The study is currently unclear on its recruitment status, but aims to enroll 30 healthy individuals.

Study design: This is a crossover, self-controlled, comparative effectiveness randomized clinical trial. It plans to enroll 30 healthy individuals.
What's involved: You will have three total visits, with measurements taken at baseline, 5 minutes after treatment, and 4 hours after treatment during each visit.
Compensation: Not stated in the trial record.
Follow-up: Measurements are taken up to 4 hours post-intervention during each visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

ImmunoBoost: The Lymphatic Osteopathic Manipulative Treatment Protocol Study

Active, Not Recruiting

NAAges 18+InterventionalPrevention

Western University of Health Sciences

~30 participants

Updated 2026-08-19 on ClinicalTrials.gov

What's tested:Osteopathic Manipulative Treatment (OMT)Sham Light TouchExercise Protocol

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Complete Blood Count (CBC) with differential

Measured over Baseline to 5 minutes post-intervention to 4 hours post-intervention.

Conditions

Healthy

Where it's being run

1 sites across 1 states

California1

Study leadership

Brian Loveless, DO · PRINCIPAL_INVESTIGATOR · Professor of NMM/OMM and Chief Medical Officer of WesternU Health

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Individuals must be 18 years or older.

Individuals must provide informed consent.

Individuals must be healthy with a BMI under 30, with no primary or secondary immune deficiency or autoimmune disease/must not be immunocompromised.

Individuals must not be using or recently have used any immune-altering medications such as corticosteroids, cyclosporin, tacrolimus, and pimecrolimus

Individuals must not have had lymphatic OMT or other physical manipulation such as acupuncture, physical therapy, chiropractic, or massage therapy in the previous four weeks before study enrollment.

Individuals must have the ability to receive OMT with lymphatic techniques.

Individuals must be able to tolerate 12 minutes of moderate physical activity.

Individuals must not be pregnant or breastfeeding.

Individuals must not have had a splenectomy or other spleen or oncologic surgery within the past 6 months.

Individuals must be infection-free for the past 6 weeks before starting the study and have not received any immunizations within the past 6 weeks.

Individuals must be willing to avoid strenuous activity at least 24 hours before each visit.

Individuals must be willing to abstain from moderate to intense activity in the 4 hours between their 2nd blood draw and their final blood draw at each of their three visits.

Exclusion

Individuals are younger than 18 years of age.

Individuals who do not provide informed consent.

Individuals with a BMI over 30, or with primary or secondary immune deficiency or autoimmune disease or is immunocompromised.

Individuals using or recently have used any immune-altering medications such as corticosteroids, cyclosporin, tacrolimus, and pimecrolimus

Individuals who have had lymphatic OMT or other physical manipulation such as acupuncture, physical therapy, chiropractic, or massage therapy in the previous four weeks before study enrollment.

Individuals who don't have the ability to receive OMT with lymphatic techniques.

Individuals who cannot tolerate 12 minutes of moderate physical activity.

Individuals who are pregnant or breastfeeding.

Individuals who have had a splenectomy or other spleen or oncologic surgery within the past 6 months.

Individuals who have had an infection in the 6 weeks before starting the study and or have received any immunizations within the past 6 weeks.

Individuals not willing to avoid strenuous activity at least 24 hours before each visit.

Individuals not willing to abstain from moderate to intense activity in the 4 hours between their 2nd blood draw and their final blood draw at each of their three visits.

What this trial measures

Complete Blood Count (CBC) with differentialBaseline to 5 minutes post-intervention to 4 hours post-intervention.
CBC with differential will be evaluated to identify the number of circulating plasma leukocytes for each intervention for each of the three interventions at three time points for each visit/intervention. This test will help us identify levels of erythrocytes, platelets, and leukocytes, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. This will be compared across time points for OMT, sham treatment, and exercise.

Trialytics