Honokiol for Early-Stage Lung Cancer Before Surgery
This study is testing a dietary supplement called honokiol in people with early-stage non-small cell lung cancer (NSCLC) before they have surgery. The main goal is to find the highest dose of honokiol that can be given safely (Maximum Tolerated Dose). You might be able to join if you are 18 or older, have early-stage NSCLC (stage I, less than 4 cm) that is planned for surgery, and are able to give written consent. About 15 patients will take honokiol for two weeks before their surgery. The study status is currently unclear.
- Study design
- This is a Phase I study, meaning it focuses on safety. It plans to enroll about 15 participants.
- What's involved
- Participants will take honokiol orally for 2 weeks prior to surgery. The dose may increase based on how well it's tolerated.
- Compensation
- Not stated in the trial record.
- Follow-up
- The Maximum Tolerated Dose will be assessed up to 21 days after the last patient starts treatment, and up to 2 years after the first patient enrolls.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jun Zhang, MD · PRINCIPAL_INVESTIGATOR · Houston Methodist Neal Cancer Center
Who to contact
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What this trial measures
- Maximum Tolerated Dose of Honokiol therapyFrom treatment initiation of each patient, assessed up to 21 days after treatment initiation of final patient, up to 2 years after first enrollment.
To determine the maximum tolerated dose (MTD) of honokiol therapy in patients with stage I NSCLC, less than 4 cm, who will undergo surgical resection. Review the safety data to determine the dose level at which the maximum tolerable level of toxicity is observed and select as the MTD the dose for which the isotonic estimate of the DLT rate is closest to the target DLT rate.