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Understanding Cancer-Related Fatigue in NSCLC Patients on Immunotherapy

This observational study aims to understand cancer-related fatigue in people with non-small cell lung cancer (NSCLC) who are receiving immunotherapy, specifically checkpoint inhibitors. Researchers will conduct interviews with about 20 participants to learn about their experiences with fatigue. You might be able to join if you are at least 18 years old, speak English, have NSCLC, and are currently receiving immunotherapy. The study will look for common themes in what patients say about their fatigue, with initial findings expected around 3 months into the study. The current recruitment status is unclear.

Study design
This is an observational study involving about 20 participants. It is not testing a new treatment but rather observing and understanding experiences.
What's involved
You would participate in two interviews, one primary and one follow-up. During the primary interview, you will also complete a short questionnaire about your fatigue.
Compensation
Not stated in the trial record.
Follow-up
Your fatigue will be measured at 3 months, and you will have a follow-up interview to discuss changes in your fatigue and views on physical activity.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06567704

Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung Cancer (NSCLC): a Qualitative Study

Recruiting
Not specifiedAges 18+Observational
Wake Forest University Health Sciences
~20 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Interviews

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Themes from qualitative interviews with patients
Measured over At 3 months

Conditions

Non-small Cell Lung Cancer

Explore related trials

Lung Non-Small Cell Carcinoma

Where it's being run

2 sites across 1 states
North Carolina2

Study leadership

  • Dori Beeler, PhD · PRINCIPAL_INVESTIGATOR · Atrium Health Levine Cancer

Who to contact

Megan Lattanze
[email protected]
(980) 442-4239
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

≥ 18 years of age at the time of consent.
Must be able to speak, read, and understand English.
Participants diagnosed with NSCLC, and:
have advanced/metastatic disease who are currently receiving immunotherapy monotherapy, or
have locally advanced disease who are currently receiving immunotherapy monotherapy after completing thoracic radiation therapy, or
who underwent resection and are currently receiving immunotherapy monotherapy after completing all other perioperative treatment
Immunotherapy planned to continue for at least three months after the time of study enrollment (to ensure participant remains on IO long enough to obtain study assessments)
Have completed at least two cycles of immunotherapy.
Self-reported cancer-related fatigued that impacts daily function.

Exclusion

Participants who have received a dose of chemotherapy (including maintenance pemetrexed) within the past 3 months
Participants who have received radiation therapy within the past 3 months. Note: a short course of palliative radiation therapy within up to 20 Gy and up to 5 fractions is permissible.
Diagnosis of dementia.
Anemia Hgb \<10 g/dL.
Sarcopenia which is being pharmacologically treated with a prescribed appetite stimulant (e.g., megestrol).
Untreated hypothyroidism.
Symptomatic heart failure.
Oxygen dependent lung disease.
Cognitively unable to complete interviews per investigator.

What this trial measures

  • Themes from qualitative interviews with patientsAt 3 months

    Two semi-structured qualitative interviews will be conducted with 20 patients. Themes will be determined through inductive analysis and will focus on key aspects of symptomatic fatigue, including but not limited to the frequency, duration, and severity of CRF and resulting functional impairments. In addition, history of physical activity before diagnosis, preferences for physical activity to treat CRF, and support needed to adhere to physical activity regimens will be considered. Themes from the first and second interviews will be synthesized to capture changes in fatigue and views on physical activity.