A Study of Cannabidiol in Young Adult Cannabis Users

This study is looking at how Broad Spectrum Cannabidiol (bsCBD) might help young adults (ages 18-25) who use cannabis regularly and have symptoms of cannabis use disorder (CUD). You could be eligible if you use cannabis frequently, are not trying to quit, and meet certain criteria for CUD. The study aims to see if taking 400 mg of bsCBD daily, compared to a placebo (an inactive substance), can reduce the harms linked to cannabis use. Researchers will measure differences in cannabis use and levels of cannabis-related substances in your blood over 8 weeks to see if bsCBD has a positive effect. The current recruitment status is unclear.

Study design
This is an interventional study with 200 planned participants. Participants will be randomly assigned to receive either Broad Spectrum Cannabidiol (bsCBD) or a placebo.
What's involved
Participants will take medication by mouth with food in the morning and evening. Blood samples will be taken at baseline, 4 weeks, and 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured at 8 weeks, indicating a follow-up period of at least 8 weeks.

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NCT06569394

A Study of Cannabidiol in Young Adult Cannabis Users

Recruiting
PHASE2Ages 18–25Interventional
University of Colorado, Denver
~200 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Broad Spectrum Cannabidiol (bsCBD) 400 mgPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in blood THC-COOH levels
Measured over 8 weeks
+2 more outcomes measured
Cannabis Use Disorder
1 sites across 1 states
Colorado1
  • Christian J Hopfer, MD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

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  • Difference in blood THC-COOH levels8 weeks

    THC-COOH levels in blood samples collected at baseline, Week 4, and Week 8 of medication ingestion.

  • Difference in blood THC levels1 hour pre and post THC self-administration at baseline, 4 weeks, and 8 weeks

    THC levels in blood samples collected before and after cannabis use at baseline, Week 4, and Week 8 of medication ingestion.

  • Difference in cannabis use8 Weeks

    Total number of days of cannabis use during the 8-week medication period as reported on daily diaries.