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Topical Treatments for Facial Wrinkles in Post-Menopausal Women

This study is looking at how different topical products affect facial wrinkles, pigmentation (skin discoloration), and skin elasticity in post-menopausal women. Researchers are testing three different products: almond oil, almond oil with 0.5% Vitamin E, and 0.025% Tretinoin (a form of Vitamin A) oil with castor oil. You would apply one of these products to your face nightly. The study aims to see if these treatments can improve facial wrinkles after 16 weeks. They are looking for women aged 18 and older with fine lines and wrinkles, who are not pregnant or breastfeeding, and do not have nut or tocopherol (Vitamin E) allergies. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 90 women. Participants will be randomly assigned to use one of the three topical products.
What's involved
You would apply 1-2 drops of a randomized topical product to your entire face nightly for 16 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for measuring facial wrinkles is at 16 weeks, which suggests the study duration for treatment and observation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06571721

The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

UNKNOWN
NAAges 18+InterventionalTreatment
Integrative Skin Science and Research
~90 participants
Updated 2024-08-28 on ClinicalTrials.gov
What's tested:Topical Product: Almond OilTopical Product: Almond oil augmented with 0.5% Vitamin ETopical Product: 0.025% Tretinoin oil augmented with castor oil

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Facial wrinkles
Measured over 16 Weeks

Conditions

Collagen Degeneration
Wrinkle
Pigmentation
Elastic Skin
Sebum Deficiency

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NCT06571721

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Integrative Research Institute

    Sacramento, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Nasima Afzal
[email protected]
915-750-2463
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
Individuals with facial fine lines and wrinkles

Exclusion

Individuals who are pregnant or breastfeeding
Prisoners
Adults unable to consent
Those with a nut allergy or tocopherol allergy
Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
Antioxidant ingredients such as vitamin C or vitamin E.
Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
Topicals that contain a nut oil or nut extract as part of their ingredient list.

What this trial measures

  • Facial wrinkles16 Weeks

    Change in severity of wrinkles measured by photographic analysis (BTBP 3D Camera System)