Back to search results

Study of Photobiomodulation for Pain and Healing After Dental Surgery

This study is looking at whether a treatment called Photobiomodulation (PBM) can help reduce pain and improve healing after a type of dental surgery called endodontic microsurgery (EMS). EMS is performed on teeth that have had root canals and still have infection or cysts at the root tip. PBM uses a special laser (660 nm diode laser) to stimulate cells and help them heal. Researchers want to see if PBM can lead to less pain and better healing of the incision (cut) made during surgery. You might be able to join if you are an adult, need endodontic microsurgery, and are generally healthy. The study will measure your pain levels before, during, and about a week after surgery to see if PBM makes a difference.

Study design
This is an interventional study planning to enroll 40 participants. It compares receiving PBM treatment to a sham treatment (where the laser is not activated) immediately after surgery.
What's involved
You will undergo endodontic microsurgery. Immediately after surgery, you will receive either PBM treatment or a sham treatment. Your pain will be assessed before surgery, on the day of surgery, and 5-7 days after surgery.
Compensation
Not stated in the trial record.
Follow-up
Pain levels will be assessed up to 5-7 days after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06574152

Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery

Recruiting
NAAges 18+InterventionalTreatment
The University of Texas Health Science Center, Houston
~90 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:PBM treatmentPBM sham treatmentEMS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in pain as assessed by a Visual Analogue Scale (VAS)
Measured over preoperative assessment (baseline), in the day of the intervention (surgery day) and 5-7 days after the surgery (sutures removal appointment).

Conditions

Apical Periodontitis
Endodontically Treated Teeth
Endodontic Disease
Apical Cyst
Apical Granuloma
Periradicular Disease
Previous Endodontic Treatment

Explore related trials

Apical periodontitis

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Juliana Barros, DDS,MS · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

Who to contact

Juliana Barros, DDS,MS
[email protected]
(713) 486-4564
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

American Society of Anesthesiologists (ASA) I or II.
At least one tooth will receive EMS.
Flap design that includes at least one VRI (triangular, rectangular, papilla base or submarginal rectangular).

Exclusion

ASA III or IV.
Current heavy smokers (\>10 cigarettes/day)
Uncontrolled diabetes (HbA1c ≥ 7%) or other uncontrolled systemic diseases that may comprise healing, such as vitamin C deficiency, neutrophil deficiencies, immunodeficiency syndromes, or leukemia.
Surgical access on the palatal surface.
Acute swelling or abscess present on the day of the surgery.
Any event or condition that would make continued participation in the study not in the best interest of the subject, as determined by the investigator.
Pregnancy.
Development of any medical condition that might affect the treatment and clinical outcomes, as determined by the investigator.
Initiation of any treatment or exposure that might affect therapy's healing, as determined by the investigator.

What this trial measures

  • Change in pain as assessed by a Visual Analogue Scale (VAS)preoperative assessment (baseline), in the day of the intervention (surgery day) and 5-7 days after the surgery (sutures removal appointment).

    this is scored on a likert scale from 0(no pain), 1-3(mild pain), 4-6( moderate pain to 10(worst pain)