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Diet and Total-Body PET Scan for Psoriasis Inflammation

This study is looking at how a nutritionally balanced diet affects inflammation in people with psoriasis. Researchers will use a new type of PET scan called EXPLORER to measure inflammation throughout your body and in your skin before and after you receive dietary counseling. The goal is to see if this new PET scanner can better detect inflammation in psoriasis patients and if changing to a balanced diet can reduce this inflammation. You may be able to join if you are an adult (over 18) with psoriasis affecting at least 3% of your body, and have a BMI of 25 or higher (meaning you are overweight). The study is currently recruiting a small number of participants.

Study design
This is an interventional study with a planned enrollment of 5 participants. It is not specified if it is randomized or blinded.
What's involved
You will receive dietary counseling from a registered dietitian or nutritionist. Inflammation will be measured with a PET/CT scan at Week 0 and Week 6.
Compensation
Not stated in the trial record.
Follow-up
Your inflammation will be measured at Week 0 and Week 6, indicating a follow-up period of at least 6 weeks.

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NCT06574178

Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet

Recruiting
NAAges 18+Interventional
University of California, Davis
~5 participants
Updated 2026-06-16 on ClinicalTrials.gov
What's tested:Dietary Counseling

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Inflammation in PET/CT scan
Measured over in Week 0 and Week 6

Conditions

Psoriasis

Explore related trials

Psoriasis

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Samuel T Hwang, MD, PhD · PRINCIPAL_INVESTIGATOR · UC Davis SOM Department of Dermatology

Who to contact

Salsala Nasim, BS
[email protected]
9165512636
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults (\>18 year)
Both sexes
Must have a history of psoriasis of at least 3% body surface area affected by skin psoriasis (in a body area that the subject will allow the PI to perform several skin biopsies as noted below (optional)) and may carry a diagnosis of psoriatic arthritis as well
Patients will have a BMI of \>/=25 which is consistent with being overweight - Willing and able to fast for at least 6 hours before and for the duration of the scan visit
No strenuous exercise for 24 hours prior to being scanned
Recruited patients must habitually consume a WD-type diet that will be evaluated by using DHQ III food frequency questionnaire along with three-day food record14. Subsequently, the Healthy Eating Index will be calculated and participants with a poor dietary pattern (score below 58) will be eligible for the study15.

Exclusion

Those taking anti-diabetic oral or injected medications
Those already ingesting a caloric- or component-restricted diet
Vegan, vegetarian or food allergy or intolerance to the ingredients of the diet
\>5% change in body weight in the last 2 months
Those taking systemic medications for the purpose of treating psoriasis or psoriatic arthritis for at least 3 months prior to first PET scan or during the duration of the trial
Self-reported history of dysphoria or anxiety in closed spaces (claustrophobia)
Uncontrolled diabetes or blood glucose level greater than 180 mg/dl at the time of radiotracer injection
Body weight \>240 kg due to limitations of the scanner bed
Known inflammatory or other infectious disease that can confound assessment
Pregnant or breast-feeding (urine pregnancy test will be administered prior to start of each PET/CT session for all participants who are able to get pregnant between 18 to 60 years old, unless documented hysterectomy or bilateral ovarian removal is available, because of risks from ionizing radiation)
Inability to lie motionless on the scanner bed with the arms by the side for up to 60 minutes
Currently participating in another conflicting research study. Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only.
Unwilling to sign informed consent
Inability to understand the risks and benefits of the study
Prisoners

What this trial measures

  • Inflammation in PET/CT scanin Week 0 and Week 6

    measuring inflammation in PET imaging by calculating the maximum standardized uptake values (SUVmax) in given areas of interest (e.g., joint, blood vessel)