This observational study aims to understand the risk of dangerous heart rhythms called ventricular tachycardia (VT) in people with genetic forms of cardiomyopathy (heart muscle disease). Researchers want to see if special heart scans (cardiac MRI) and detailed heart mapping during a procedure can help identify these high-risk patients. You might be able to join if you are an adult (18 or older) diagnosed with atrial fibrillation (AF), frequent premature ventricular contractions (PVCs), or VT before age 60. You also need to be scheduled for a catheter-based ablation procedure for AF, PVCs, or VT, and have a specific genetic change (P/LP variant) in the TTN gene or another cardiomyopathy gene, or be a control without these genetic changes. The study will look at how often VT can be triggered, where it starts, and if areas of scar tissue in the heart are linked to VT risk. The goal is to better understand how genetic findings can guide treatment.

Study design

This is an observational study planning to enroll 200 participants. It is not testing a new treatment but rather observing existing conditions and procedures.

What's involved

Participants will undergo a cardiac MRI before their scheduled ablation procedure and voltage mapping during the procedure. These are part of the data collection for the study.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, ventricular tachycardia inducibility, is measured during the procedure. No further follow-up timeframes are specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.