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NCT06576687

Neurophysiology of Ankle Instability

Enrolling by Invitation
NAAges 19–45InterventionalTreatment
University of Nebraska
~42 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Physical Rehabilitation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Side-hop Test
Measured over Baseline and post-rehabilitation (six weeks total)
+2 more outcomes measured

Conditions

Ankle Injuries

Explore related trials

Chronic ankle instability

Where it's being run

1 sites across 1 states
Nebraska1

Study leadership

  • Adam B Rosen, PhD · PRINCIPAL_INVESTIGATOR · University of Nebraska

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

All participants must be physically active (participation in at least 90 total minutes of activity/week including running, walking, lifting weights, or playing a sport, etc.)
Healthy controls:
no history of lateral ankle sprain
no complaints of their ankle giving way
a Cumberland Ankle Instability Tool (CAIT) score greater than 28
Coper participants (participants coping with ankle problems:
a history of lateral ankle sprain, but no episodes of giving way in previous 12 months
CAIT score greater than 28
Chronic ankle instability (CAI):
history of ankle sprain
two or more episodes of ankle giving way in previous 12 months
CAIT score less than 25

Exclusion

History of lower extremity surgery or fracture
Current signs or symptoms of a joint sprain in the lower extremity
Pregnancy
Diagnosis of a vestibular disorder
Diagnosis of a nerve or connective tissue disorder
Significant history of condition that impaired cognitive function such as concussion or learning disability
Currently taking medications that may affect cognitive function such as narcotics, anti-depressants, anti-anxiety agents, or stimulants

What this trial measures

  • Side-hop TestBaseline and post-rehabilitation (six weeks total)

    Amount of time it takes participants to hop medially and laterally across a 30-cm gap ten times will be measured. Greater times equals worse performance.

  • Choice-reaction Hop TestBaseline and post-rehabilitation (six weeks total)

    Amount of time it takes participants hop on a mat medially and laterally across a 30-cm gap ten times, using visual cues to direct movement to one of two squares on each side. Greater times equals worse performance.

  • Inversion-eversion Force ControlBaseline and post-rehabilitation (six weeks total)

    The force control accuracy at 50% maximal contraction for eversion and inversion will be determined. This is analyzed by a non-linear analysis Lyapunov exponent (LyE) which measures the quality or the natural, inherent fluctuations in movement. Greater values indicate reduced neuromuscular control.